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Literature DB >> 15986391

Regional distribution and cellular localization of the ETS-domain transcription factor, FEV, mRNA in the human postmortem brain.

Abiye H Iyo¹, Bethany Porter, Evan S Deneris, Mark C Austin.

Abstract

The ETS transcription factor Fifth Ewing Variant (FEV) mRNA, a homologue of the rodent Pet-1 gene that is exclusively expressed in serotonin-containing neurons and is a critical determinant of serotonin neuronal differentiation and development, was examined in human postmortem brain tissue using in situ hybridization histochemistry. Studies revealed that FEV mRNA is robustly and exclusively expressed in the major serotonin-containing cell groups of the dorsal and median raphe nuclei located in the midbrain and pons of the human brainstem. The localization of transcription factor, FEV, mRNA in serotonin-containing neurons of the human brain raises questions regarding the functional significance of this transcription factor in regulating serotonin-related genes and its potential role in psychiatric illness.

Entities: Chemical Disease Gene Species

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Year: 2005 PMID： 15986391 PMCID： PMC2923919 DOI： 10.1002/syn.20178

Source DB: PubMed Journal: Synapse ISSN： 0887-4476 Impact factor: 2.562

23 in total

1. FEV acts as a transcriptional repressor through its DNA-binding ETS domain and alanine-rich domain.

Authors: Philippe Maurer; France T'Sas; Laurent Coutte; Nathalie Callens; Carmen Brenner; Carine Van Lint; Yvan de Launoit; Jean-Luc Baert
Journal: Oncogene Date: 2003-05-22 Impact factor: 9.867

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Journal: Can J Psychiatry Date: 2003-06 Impact factor: 4.356

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Journal: Neuroscience Date: 2002 Impact factor: 3.590

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Journal: Oncogene Date: 1997-03-13 Impact factor: 9.867

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Journal: Eur J Biochem Date: 1993-01-15

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Journal: Neuroscience Date: 1981 Impact factor: 3.590

7. mPet-1, a mouse ETS-domain transcription factor, is expressed in central serotonergic neurons.

Authors: Harald Pfaar; Alexander von Holst; Daniela M Vogt Weisenhorn; Claude Brodski; Jordi Guimera; Wolfgang Wurst
Journal: Dev Genes Evol Date: 2002-01-31 Impact factor: 0.900

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Authors: Craig A Stockmeier
Journal: J Psychiatr Res Date: 2003 Sep-Oct Impact factor: 4.791

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Authors: Philippe Maurer; Sandrine Rorive; Alban de Kerchove d'Exaerde; Serge N Schiffmann; Isabelle Salmon; Yvan de Launoit
Journal: Neurosci Lett Date: 2004-03-11 Impact factor: 3.046

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12 in total

1. Region-specific regulation of 5-HT1A receptor expression by Pet-1-dependent mechanisms in vivo.

Authors: Kirsten X Jacobsen; Margaret Czesak; Mariam Deria; Brice Le François; Paul R Albert
Journal: J Neurochem Date: 2011-01-24 Impact factor: 5.372

Review 2. Serotonergic transcriptional networks and potential importance to mental health.

Authors: Evan S Deneris; Steven C Wyler
Journal: Nat Neurosci Date: 2012-02-26 Impact factor: 24.884

3. GPR30 is necessary for estradiol-induced desensitization of 5-HT1A receptor signaling in the paraventricular nucleus of the rat hypothalamus.

Authors: C E McAllister; R D Creech; P A Kimball; N A Muma; Q Li
Journal: Psychoneuroendocrinology Date: 2012-01-20 Impact factor: 4.905

10. Serotonergic transcription of human FEV reveals direct GATA factor interactions and fate of Pet-1-deficient serotonin neuron precursors.

Authors: Katherine C Krueger; Evan S Deneris
Journal: J Neurosci Date: 2008-11-26 Impact factor: 6.167