Literature DB >> 15986174

Phylogenetic and recombination analysis of coronavirus HKU1, a novel coronavirus from patients with pneumonia.

P C Y Woo1, S K P Lau, Y Huang, H-W Tsoi, K-H Chan, K-Y Yuen.   

Abstract

Phylogenetic trees constructed using predicted amino acid sequences of putative proteins of coronavirus HKU1 (CoV-HKU1) revealed that CoV-HKU1 formed a distinct branch among group 2 coronaviruses. Of the 14 trees from p65 to nsp10, nine showed that CoV-HKU1 was clustered with murine hepatitis virus. From nsp11, the topologies of the trees changed dramatically. For the eight trees from nsp11 to N, seven showed that the CoV-HKU1 branch was the first branch. The codon usage patterns of CoV-HKU1 differed significantly from those in other group 2 coronaviruses. Split decomposition analysis revealed that recombination events had occurred between CoV-HKU1 and other coronaviruses.

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Year:  2005        PMID： 15986174      PMCID： PMC7086700          DOI： 10.1007/s00705-005-0573-2

Source DB:  PubMed          Journal:  Arch Virol        ISSN： 0304-8608            Impact factor:   2.574


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