Literature DB >> 15986134

A Wnt-er wonderland--the complexity of Wnt signaling in melanoma.

Ashani T Weeraratna1.   

Abstract

Wnt signaling is a complex process that requires the interplay of several different proteins. In addition to a large cohort of Wnt ligands, and frizzled receptors, some Wnt pathways also require the presence of co-receptors. Wnt ligands may activate one of three pathways, the canonical pathway, involving beta -catenin, the planar cell polarity pathway and the Wnt/ calcium pathway. All three pathways have different results for the cells in which they signal. Aberrant activation of these pathways can lead to the development and progression of several cancers. In this review we will discuss the different Wnt pathways, and their contribution to melanoma progression.

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Year:  2005        PMID： 15986134     DOI： 10.1007/s10555-005-1574-z

Source DB:  PubMed          Journal:  Cancer Metastasis Rev        ISSN： 0167-7659            Impact factor:   9.264


  28 in total

1.  DNAJB6 chaperones PP2A mediated dephosphorylation of GSK3β to downregulate β-catenin transcription target, osteopontin.

Authors:  A Mitra; M E Menezes; L K Pannell; M S Mulekar; R E Honkanen; L A Shevde; R S Samant
Journal:  Oncogene       Date:  2012-01-23       Impact factor: 9.867

Review 2.  Gene signature of the metastatic potential of cutaneous melanoma: too much for too little?

Authors:  József Tímár; Balázs Gyorffy; Erzsébet Rásó
Journal:  Clin Exp Metastasis       Date:  2010-02-24       Impact factor: 5.150

Review 3.  Melanocyte receptors: clinical implications and therapeutic relevance.

Authors:  J Andrew Carlson; Gerald P Linette; Andrew Aplin; Bernard Ng; Andrzej Slominski
Journal:  Dermatol Clin       Date:  2007-10       Impact factor: 3.478

4.  Changes in the gene expression profile of A375 human melanoma cells induced by overexpression of multifunctional pigment epithelium-derived factor.

Authors:  Jose L Orgaz; Alberto Benguria; Cristina Sanchez-Martinez; Omar Ladhani; Olga V Volpert; Benilde Jimenez
Journal:  Melanoma Res       Date:  2011-08       Impact factor: 3.599

Review 5.  A Wnt survival guide: from flies to human disease.

Authors:  Andy J Chien; William H Conrad; Randall T Moon
Journal:  J Invest Dermatol       Date:  2009-01-29       Impact factor: 8.551

6.  Activated Wnt/beta-catenin signaling in melanoma is associated with decreased proliferation in patient tumors and a murine melanoma model.

Authors:  Andy J Chien; Erin C Moore; Anke S Lonsdorf; Rima M Kulikauskas; Bonnie Gould Rothberg; Aaron J Berger; Michael B Major; Sam T Hwang; David L Rimm; Randall T Moon
Journal:  Proc Natl Acad Sci U S A       Date:  2009-01-14       Impact factor: 11.205

7.  CTLA-4 is a direct target of Wnt/beta-catenin signaling and is expressed in human melanoma tumors.

Authors:  Kavita V Shah; Andy J Chien; Cassian Yee; Randall T Moon
Journal:  J Invest Dermatol       Date:  2008-06-19       Impact factor: 8.551

8.  Lack of Wnt5A expression in Merkel cell carcinoma.

Authors:  Ashani T Weeraratna; Roland Houben; Michael P O'Connell; Jürgen C Becker
Journal:  Arch Dermatol       Date:  2010-01

9.  Activation of the canonical Wnt/β-catenin signalling pathway is rare in canine malignant melanoma tissue and cell lines.

Authors:  E Chon; V Thompson; S Schmid; T J Stein
Journal:  J Comp Pathol       Date:  2012-08-14       Impact factor: 1.311

Review 10.  G-protein-coupled receptors and melanoma.

Authors:  Hwa Jin Lee; Brian Wall; Suzie Chen
Journal:  Pigment Cell Melanoma Res       Date:  2008-05-27       Impact factor: 4.693
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