Adrian Heard1, David Roder, Colin Luke. 1. Department of Health, Epidemiology Branch, Adelaide, South Australia. Adrian.Heard@health.sa.gov.au
Abstract
OBJECTIVE: To identify cancers which occur as second primaries following the diagnosis of cancers of other sites, as a basis for formulating causal hypotheses and planning medical surveillance. METHODS: Analyses of fifteen common cancer sites were undertaken to examine the occurrence of multiple primaries. These cancers were notified to the South Australian Cancer Registry during 1977-2001. Historic cohort models were used where standardised incidence ratios (95 confidence limits) were calculated to indicate the risk of second primary cancers. RESULTS: New associations detected included an increased risk of cancers of the bladder, colon, rectum, kidney and melanomas following a diagnosis of prostate cancer and an increased risk of leukaemia following both lung and rectal cancer. Many previously identified combinations of multiple primaries were confirmed. CONCLUSIONS: From the wide range of associations identified, some such as leukaemias occurring as second primaries after the diagnosis of ovarian cancers and lymphomas may be a treatment effect. The diagnosis of multiple primary cancers in the same month (e.g. bladder-prostate cancers and ovarian-uterine cancers) may reflect patterns of medical testing and the long preclinical phases of some cancers.
OBJECTIVE: To identify cancers which occur as second primaries following the diagnosis of cancers of other sites, as a basis for formulating causal hypotheses and planning medical surveillance. METHODS: Analyses of fifteen common cancer sites were undertaken to examine the occurrence of multiple primaries. These cancers were notified to the South Australian Cancer Registry during 1977-2001. Historic cohort models were used where standardised incidence ratios (95 confidence limits) were calculated to indicate the risk of second primary cancers. RESULTS: New associations detected included an increased risk of cancers of the bladder, colon, rectum, kidney and melanomas following a diagnosis of prostate cancer and an increased risk of leukaemia following both lung and rectal cancer. Many previously identified combinations of multiple primaries were confirmed. CONCLUSIONS: From the wide range of associations identified, some such as leukaemias occurring as second primaries after the diagnosis of ovarian cancers and lymphomas may be a treatment effect. The diagnosis of multiple primary cancers in the same month (e.g. bladder-prostate cancers and ovarian-uterine cancers) may reflect patterns of medical testing and the long preclinical phases of some cancers.
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