PURPOSE OF REVIEW: The aim of this article is to analyze the chemical reactivity of cephalosporins resulting in the epitope responsible for recognition by IgE antibodies and to establish the basis of the allergenicity. RECENT FINDINGS: Increasing evidence supports the role of cephalosporins in IgE hypersensitivity reactions. Third and fourth generation cephalosporins appear to be more involved in specific IgE reactions and often no cross-reactivity with traditional benzyl penicillin determinants exists. In some instances selective responses to unique cephalosporins occur and in others common side-chain similarities exist. SUMMARY: Lack of knowledge of the exact chemical structure of cephalosporin antigenic determinants has hindered clinical interpretation of allergic reactions to these drugs and hampered understanding of the specific recognition by IgE molecules of these determinants. Data indicate that R2 is not present in the final conjugate and that recognition by IgE antibodies is mainly directed to the R1 acyl side chain and to the beta-lactam fragment that remains linked to the carrier protein in the cephalosporin conjugation process.
PURPOSE OF REVIEW: The aim of this article is to analyze the chemical reactivity of cephalosporins resulting in the epitope responsible for recognition by IgE antibodies and to establish the basis of the allergenicity. RECENT FINDINGS: Increasing evidence supports the role of cephalosporins in IgE hypersensitivity reactions. Third and fourth generation cephalosporins appear to be more involved in specific IgE reactions and often no cross-reactivity with traditional benzyl penicillin determinants exists. In some instances selective responses to unique cephalosporins occur and in others common side-chain similarities exist. SUMMARY: Lack of knowledge of the exact chemical structure of cephalosporin antigenic determinants has hindered clinical interpretation of allergic reactions to these drugs and hampered understanding of the specific recognition by IgE molecules of these determinants. Data indicate that R2 is not present in the final conjugate and that recognition by IgE antibodies is mainly directed to the R1 acyl side chain and to the beta-lactam fragment that remains linked to the carrier protein in the cephalosporin conjugation process.
Authors: Akito Kawai; Christi L McElheny; Alina Iovleva; Ellen G Kline; Nicolas Sluis-Cremer; Ryan K Shields; Yohei Doi Journal: Antimicrob Agents Chemother Date: 2020-06-23 Impact factor: 5.191
Authors: Christopher Kupitz; Jose L Olmos; Mark Holl; Lee Tremblay; Kanupriya Pande; Suraj Pandey; Dominik Oberthür; Mark Hunter; Mengning Liang; Andrew Aquila; Jason Tenboer; George Calvey; Andrea Katz; Yujie Chen; Max O Wiedorn; Juraj Knoska; Alke Meents; Valerio Majriani; Tyler Norwood; Ishwor Poudyal; Thomas Grant; Mitchell D Miller; Weijun Xu; Aleksandra Tolstikova; Andrew Morgan; Markus Metz; Jose M Martin-Garcia; James D Zook; Shatabdi Roy-Chowdhury; Jesse Coe; Nirupa Nagaratnam; Domingo Meza; Raimund Fromme; Shibom Basu; Matthias Frank; Thomas White; Anton Barty; Sasa Bajt; Oleksandr Yefanov; Henry N Chapman; Nadia Zatsepin; Garrett Nelson; Uwe Weierstall; John Spence; Peter Schwander; Lois Pollack; Petra Fromme; Abbas Ourmazd; George N Phillips; Marius Schmidt Journal: Struct Dyn Date: 2016-12-15 Impact factor: 2.920
Authors: Melissa D Barnes; Magdalena A Taracila; Joseph D Rutter; Christopher R Bethel; Ioannis Galdadas; Andrea M Hujer; Emilia Caselli; Fabio Prati; John P Dekker; Krisztina M Papp-Wallace; Shozeb Haider; Robert A Bonomo Journal: mBio Date: 2018-12-11 Impact factor: 7.867