Literature DB >> 1598579

Nondissociation of GAL4 and GAL80 in vivo after galactose induction.

K K Leuther1, S A Johnston.   

Abstract

Transcription of galactose-inducible genes in yeast is regulated by interaction between the activator protein GAL4 and the negative regulatory protein GAL80. It has been suggested that GAL80 binds to and represses GAL4 under uninduced conditions and dissociates from GAL4 on induction. However, the possibility that GAL80 remains associated with GAL4 after induction has not been ruled out. Experiments to discriminate between these two models were performed and revealed that GAL80 stays bound after induction.

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Year:  1992        PMID： 1598579     DOI： 10.1126/science.1598579

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  62 in total

1.  Glucose represses the lactose-galactose regulon in Kluyveromyces lactis through a SNF1 and MIG1- dependent pathway that modulates galactokinase (GAL1) gene expression.

Authors:  J Dong; R C Dickson
Journal:  Nucleic Acids Res       Date:  1997-09-15       Impact factor: 16.971

2.  A transcriptionally active form of GAL4 is phosphorylated and associated with GAL80.

Authors:  M R Parthun; J A Jaehning
Journal:  Mol Cell Biol       Date:  1992-11       Impact factor: 4.272

3.  Molecular simulation and docking studies of Gal1p and Gal3p proteins in the presence and absence of ligands ATP and galactose: implication for transcriptional activation of GAL genes.

Authors:  Sanjay K Upadhyay; Yellamraju U Sasidhar
Journal:  J Comput Aided Mol Des       Date:  2012-05-26       Impact factor: 3.686

4.  Nuclear export of the transcription factor NirA is a regulatory checkpoint for nitrate induction in Aspergillus nidulans.

Authors:  Andreas Bernreiter; Ana Ramon; Javier Fernández-Martínez; Harald Berger; Lidia Araújo-Bazan; Eduardo A Espeso; Robert Pachlinger; Andreas Gallmetzer; Ingund Anderl; Claudio Scazzocchio; Joseph Strauss
Journal:  Mol Cell Biol       Date:  2006-11-20       Impact factor: 4.272

5.  The role of the proteasomal ATPases and activator monoubiquitylation in regulating Gal4 binding to promoters.

Authors:  Anwarul Ferdous; Devanjan Sikder; Thomas Gillette; Kip Nalley; Thomas Kodadek; Stephen Albert Johnston
Journal:  Genes Dev       Date:  2006-12-13       Impact factor: 11.361

6.  Gene activation by dissociation of an inhibitor from a transcriptional activation domain.

Authors:  Fenglei Jiang; Benjamin R Frey; Margery L Evans; Jordan C Friel; James E Hopper
Journal:  Mol Cell Biol       Date:  2009-08-03       Impact factor: 4.272

Review 7.  Recent advances in nitrogen regulation: a comparison between Saccharomyces cerevisiae and filamentous fungi.

Authors:  Koon Ho Wong; Michael J Hynes; Meryl A Davis
Journal:  Eukaryot Cell       Date:  2008-04-25

8.  Localization and interaction of the proteins constituting the GAL genetic switch in Saccharomyces cerevisiae.

Authors:  Raymond Wightman; Rachel Bell; Richard J Reece
Journal:  Eukaryot Cell       Date:  2008-10-24

9.  Poly(A) signals control both transcriptional termination and initiation between the tandem GAL10 and GAL7 genes of Saccharomyces cerevisiae.

Authors:  I H Greger; N J Proudfoot
Journal:  EMBO J       Date:  1998-08-17       Impact factor: 11.598

10.  Functional analysis of the PUT3 transcriptional activator of the proline utilization pathway in Saccharomyces cerevisiae.

Authors:  S A des Etages; D A Falvey; R J Reece; M C Brandriss
Journal:  Genetics       Date:  1996-04       Impact factor: 4.562
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