Z M Patel1, R A Adhia. 1. Genetic Research Centre, National Institute for Research in Reproductive Health, Parel, Mumbai, India. zmpatel@hotmail.com
Abstract
OBJECTIVE: To study the overall frequency of congenital malformations in a city hospital in the first three days of life. METHODS: 17,653 consecutive newborns were examined and diagnosed at a maternity hospital by pediatricians and geneticists. Relevant information was documented on a predesigned proforma and analyzed. RESULTS: Of the 17,653 births 294 (1; 6%) had major malformations and 1400 (7.92%) had minor malformations. Amongst 17,653 births 328 (1.8%) were stillbirths. Malformations were highest in this group. Polygenic traits accounted for 45.1% while chromosomal etiology was found in 4%. A genetic basis was found in 65.4% of cases. CONCLUSION: With emphasis on ''small family '' norms & population control it is necessary to identify malformations so that Interventional programmes can be planned.
OBJECTIVE: To study the overall frequency of congenital malformations in a city hospital in the first three days of life. METHODS: 17,653 consecutive newborns were examined and diagnosed at a maternity hospital by pediatricians and geneticists. Relevant information was documented on a predesigned proforma and analyzed. RESULTS: Of the 17,653 births 294 (1; 6%) had major malformations and 1400 (7.92%) had minor malformations. Amongst 17,653 births 328 (1.8%) were stillbirths. Malformations were highest in this group. Polygenic traits accounted for 45.1% while chromosomal etiology was found in 4%. A genetic basis was found in 65.4% of cases. CONCLUSION: With emphasis on ''small family '' norms & population control it is necessary to identify malformations so that Interventional programmes can be planned.
Authors: Osaretin U Chimah; Kennedy N Emeagui; Obinna C Ajaegbu; Chioma V Anazor; Chukwuma A Ossai; Adeniyi J Fagbemi; Omoadoni D Emeagui Journal: Health Sci Rep Date: 2022-04-13
Authors: Bahauddin I Sallout; Manal S Al-Hoshan; Reham A Attyyaa; Abdelmane A Al Suleimat Journal: Ann Saudi Med Date: 2008 Jul-Aug Impact factor: 1.526