Literature DB >> 15985372

Semi-automated preparation of the dopamine transporter ligand [(18)F]FECNT for human PET imaging studies.

Ronald J Voll1, Jonathan McConathy, Michael S Waldrep, Ronald J Crowe, Mark M Goodman.   

Abstract

The fluorine-18 labeled dopamine transport (DAT) ligand 2 beta-carbomethoxy-3beta-(4-chlorophenyl)-8-(2-fluoroethyl)nortropane (FECNT) has shown promising properties as an in vivo DAT imaging agent in human and monkey PET studies. A semi-automated synthesis has been developed to reliably produce [(18)F]FECNT in a 16% decay corrected yield. This method utilizes a new [(18)F]fluoralkylating agent and provides high purity [(18)F]FECNT in a formulation suitable for human use.

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Year:  2005        PMID： 15985372     DOI： 10.1016/j.apradiso.2005.04.008

Source DB:  PubMed          Journal:  Appl Radiat Isot        ISSN： 0969-8043            Impact factor:   1.513


  6 in total

1.  Syntheses and biological activities of novel 2-methoxyestradiol analogs, 2-fluoroethoxyestradiol and 2-fluoropropanoxyestradiol, and a radiosynthesis of 2-[(18)F]fluoroethoxyestradiol for positron emission tomography.

Authors:  Jiyoung Mun; Yuefang Wang; Ronald J Voll; Daniel Escuin-Borras; Paraskevi Giannakakou; Mark M Goodman
Journal:  Nucl Med Biol       Date:  2008-07       Impact factor: 2.408

2.  Synthesis and evaluation of C-11, F-18 and I-125 small molecule radioligands for detecting oxytocin receptors.

Authors:  Aaron L Smith; Sara M Freeman; Jeffery S Stehouwer; Kiyoshi Inoue; Ronald J Voll; Larry J Young; Mark M Goodman
Journal:  Bioorg Med Chem       Date:  2012-02-25       Impact factor: 3.641

3.  Fluorine-18 Radiolabeled PET Tracers for Imaging Monoamine Transporters: Dopamine, Serotonin, and Norepinephrine.

Authors:  Jeffrey S Stehouwer; Mark M Goodman
Journal:  PET Clin       Date:  2009-01

Review 4.  Strained Ammonium Precursors for Radiofluorinations.

Authors:  Falco Reissig; Constantin Mamat
Journal:  ChemistryOpen       Date:  2022-06       Impact factor: 2.630

5.  An efficient synthesis of dopamine transporter tracer [¹⁸F]FECNT.

Authors:  D Murali; T E Barnhart; N T Vandehey; B T Christian; R J Nickles; A K Converse; J A Larson; J E Holden; M L Schneider; O T Dejesus
Journal:  Appl Radiat Isot       Date:  2012-10-23       Impact factor: 1.513

6.  Quantification of dopamine transporter density with [18F]FECNT PET in healthy humans.

Authors:  Jonathon A Nye; John R Votaw; J Douglas Bremner; Margaret R Davis; Ronald J Voll; Vernon M Camp; Mark M Goodman
Journal:  Nucl Med Biol       Date:  2013-12-26       Impact factor: 2.408
  6 in total

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