Literature DB >> 15984565

Exposure to high fluoride concentration in drinking water will affect spermatogenesis and steroidogenesis in male albino rats.

T Pushpalatha1, M Srinivas, P Sreenivasula Reddy.   

Abstract

Sodium fluoride (NaF) administered orally to adult male rats at a dose level of 4.5 ppm and 9.0 ppm for 75 days caused significant decrease in the body weight, brain index and testicular index. A significant decrease in sperm count, sperm motility, sperm viability and sperm function (HOS positive) with increased sperm abnormalities was also observed in NaF-exposed male rats. The activity levels of testicular steroidogenic marker enzymes 3beta-hydroxysteroid dehydrogenase (3beta-HSD) and 17beta-hydroxysteroid dehydrogenase (17beta-HSD) were significantly decreased in NaF-treated rats indicating decreased steroidogenesis and in turn spermatogenesis in rats exposed to NaF.

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Year:  2005        PMID： 15984565     DOI： 10.1007/s10534-005-0336-2

Source DB:  PubMed          Journal:  Biometals        ISSN： 0966-0844            Impact factor:   2.949


  5 in total

1.  Kinetic analysis of decreased sperm fertilizing ability by fluorides and fluoroaluminates: a tool for analyzing the effect of environmental substances on biological events.

Authors:  Zuzana Bosakova; Antonin Tockstein; Hana Adamusova; Pavel Coufal; Natasa Sebkova; Katerina Dvorakova-Hortova
Journal:  Eur Biophys J       Date:  2015-09-22       Impact factor: 1.733

2.  Suppression of male reproduction in rats after exposure to sodium fluoride during early stages of development.

Authors:  P Sreedhar Reddy; T Pushpalatha; P Sreenivasula Reddy
Journal:  Naturwissenschaften       Date:  2007-02-22

3.  Evaluation of the protective effects of icariin on nicotine-induced reproductive toxicity in male mouse -a pilot study.

Authors:  Guochao Ni; Xuhui Zhang; Seth Yaw Afedo; Rong Rui
Journal:  Reprod Biol Endocrinol       Date:  2020-06-18       Impact factor: 5.211

4.  Vitamin E and lycopene reduce coal burning fluorosis-induced spermatogenic cell apoptosis via oxidative stress-mediated JNK and ERK signaling pathways.

Authors:  Yuan Tian; Yuehai Xiao; Bolin Wang; Chao Sun; Kaifa Tang; Fa Sun
Journal:  Biosci Rep       Date:  2018-07-31       Impact factor: 3.840

5.  Exposure of Fluoride with Streptozotocin-Induced Diabetes Aggravates Testicular Damage and Spermatozoa Parameters in Mice.

Authors:  Manuel Sánchez-Gutiérrez; Evelia Martínez-Loredo; Eduardo Osiris Madrigal-Santillán; Gabriel Betanzos-Cabrera; Araceli Hernández-Zavala; María Angélica Mojica-Villegas; Jeannett Alejandra Izquierdo-Vega
Journal:  J Toxicol       Date:  2019-12-03
  5 in total

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