Literature DB >> 15983417

Structure of insect-cell-derived IL-22.

Ting Xu1, Naomi J Logsdon, Mark R Walter.   

Abstract

The crystal structure of interleukin-22 expressed in Drosophila melanogaster S2 cells (IL-22(Dm)) has been determined at 2.6 A resolution. IL-22(Dm) crystals contain six molecules in the asymmetric unit. Comparison of IL-22(Dm) and IL-22(Ec) (interleukin-22 produced in Escherichia coli) structures reveals that N-linked glycosylation causes only minor structural changes to the cytokine. However, 1-4 A main-chain differences are observed between the six IL-22(Dm) monomers at regions corresponding to the IL-22R1 and IL-10R2 binding sites. The structure of the carbohydrate and the conformational variation of IL22(Dm) provide new insights into IL-22 receptor recognition.

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Year:  2005        PMID： 15983417     DOI： 10.1107/S0907444905009601

Source DB:  PubMed          Journal:  Acta Crystallogr D Biol Crystallogr        ISSN： 0907-4449


  19 in total

Review 1.  Structure and function of interleukin-22 and other members of the interleukin-10 family.

Authors:  Daniela Barretto Barbosa Trivella; José Ribamar Ferreira-Júnior; Laure Dumoutier; Jean-Christophe Renauld; Igor Polikarpov
Journal:  Cell Mol Life Sci       Date:  2010-05-08       Impact factor: 9.261

2.  Structure of IL-22 bound to its high-affinity IL-22R1 chain.

Authors:  Brandi C Jones; Naomi J Logsdon; Mark R Walter
Journal:  Structure       Date:  2008-07-03       Impact factor: 5.006

3.  Structure-based design of a protein immunogen that displays an HIV-1 gp41 neutralizing epitope.

Authors:  Robyn L Stanfield; Jean-Philippe Julien; Robert Pejchal; Johannes S Gach; Michael B Zwick; Ian A Wilson
Journal:  J Mol Biol       Date:  2011-10-15       Impact factor: 5.469

4.  Structural mapping of post-translational modifications in human interleukin-24: role of N-linked glycosylation and disulfide bonds in secretion and activity.

Authors:  Kerry L Fuson; Mingzhong Zheng; Molly Craxton; Abujiang Pataer; Rajagopal Ramesh; Sunil Chada; R Bryan Sutton
Journal:  J Biol Chem       Date:  2009-09-04       Impact factor: 5.157

Review 5.  Interleukin-22: immunobiology and pathology.

Authors:  Jarrod A Dudakov; Alan M Hanash; Marcel R M van den Brink
Journal:  Annu Rev Immunol       Date:  2015-02-11       Impact factor: 28.527

Review 6.  Structural analysis of cytokines comprising the IL-10 family.

Authors:  Alexander Zdanov
Journal:  Cytokine Growth Factor Rev       Date:  2010-09-16       Impact factor: 7.638

7.  Crystal Structure of the Labile Complex of IL-24 with the Extracellular Domains of IL-22R1 and IL-20R2.

Authors:  Jacek Lubkowski; Cem Sonmez; Sergey V Smirnov; Andriy Anishkin; Sergei V Kotenko; Alexander Wlodawer
Journal:  J Immunol       Date:  2018-08-15       Impact factor: 5.422

8.  Crystal structure of human interferon-λ1 in complex with its high-affinity receptor interferon-λR1.

Authors:  Zachary J Miknis; Eugenia Magracheva; Wei Li; Alexander Zdanov; Sergei V Kotenko; Alexander Wlodawer
Journal:  J Mol Biol       Date:  2010-10-08       Impact factor: 5.469

9.  Interleukin-22 forms dimers that are recognized by two interleukin-22R1 receptor chains.

Authors:  Mario de Oliveira Neto; José Ribamar Ferreira; Didier Colau; Hannes Fischer; Alessandro S Nascimento; Aldo F Craievich; Laure Dumoutier; Jean-Christophe Renauld; Igor Polikarpov
Journal:  Biophys J       Date:  2007-11-16       Impact factor: 4.033

Review 10.  The molecular basis of IL-10 function: from receptor structure to the onset of signaling.

Authors:  Mark R Walter
Journal:  Curr Top Microbiol Immunol       Date:  2014       Impact factor: 4.291
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