| Literature DB >> 15982881 |
Xiaojun Han1, Sokhom S Pin, Kevin Burris, Lawrence K Fung, Stella Huang, Matthew T Taber, Jie Zhang, Gene M Dubowchik.
Abstract
8-Aryl-1,3a,8-triaza-cyclopenta[a]indenes represent a novel series of high binding affinity corticotropin-releasing factor 1 receptor antagonists. Here, we report their synthesis, SAR, and pharmacokinetic properties of compound 8e (K(i) = 23 nM).Entities:
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Year: 2005 PMID： 15982881 DOI： 10.1016/j.bmcl.2005.06.028
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823