Literature DB >> 15982783

Expression of the human melanocortin-2 receptor in different eukaryotic cells.

Mohamed Rached1, Haquima El Mourabit, Anna Buronfosse, Antonine Blondet, Danielle Naville, Martine Begeot, Armelle Penhoat.   

Abstract

The human melanocortin-2 receptor (hMC2R) is mainly present in the adrenal cortex and has been difficult to express in heterologous cells. The hMC2R fused to the EGFP at its C-terminus has been stably transfected in the murine M3 melanoma and HEK293 cells. In the M3 cells, the hMC2R-EGFP was well-addressed to the cell membrane and functional whereas in the HEK293 cells, the hMC2R-EGFP was retained intracellularly. These results suggest that some specific factors, missing in cells, which do not express any melanocortin receptor, are involved in the correct addressing of the hMC2R to the cell membrane.

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Year:  2005        PMID： 15982783     DOI： 10.1016/j.peptides.2004.11.037

Source DB:  PubMed          Journal:  Peptides        ISSN： 0196-9781            Impact factor:   3.750


  9 in total

1.  Mechanisms of melanocortin-2 receptor (MC2R) internalization and recycling in human embryonic kidney (hek) cells: identification of Key Ser/Thr (S/T) amino acids.

Authors:  Simon Roy; Sébastien Jean Roy; Sandra Pinard; Louis-Daniel Taillefer; Mohamed Rached; Jean-Luc Parent; Nicole Gallo-Payet
Journal:  Mol Endocrinol       Date:  2011-09-15

2.  Adrenocorticotropic Hormone (ACTH) Responses Require Actions of the Melanocortin-2 Receptor Accessory Protein on the Extracellular Surface of the Plasma Membrane.

Authors:  Sundeep Malik; Terrance M Dolan; Zachary J Maben; Patricia M Hinkle
Journal:  J Biol Chem       Date:  2015-09-30       Impact factor: 5.157

3.  Differential Signaling Profiles of MC4R Mutations with Three Different Ligands.

Authors:  Sarah Paisdzior; Ioanna Maria Dimitriou; Paul Curtis Schöpe; Paolo Annibale; Patrick Scheerer; Heiko Krude; Martin J Lohse; Heike Biebermann; Peter Kühnen
Journal:  Int J Mol Sci       Date:  2020-02-12       Impact factor: 5.923

4.  A Setmelanotide-like Effect at MC4R Is Achieved by MC4R Dimer Separation.

Authors:  Nanina Reininghaus; Sarah Paisdzior; Friederike Höpfner; Sabine Jyrch; Cigdem Cetindag; Patrick Scheerer; Peter Kühnen; Heike Biebermann
Journal:  Biomolecules       Date:  2022-08-15

5.  MRAP and MRAP2 are bidirectional regulators of the melanocortin receptor family.

Authors:  Li F Chan; Tom R Webb; Teng-Teng Chung; Eirini Meimaridou; Sadani N Cooray; Leonardo Guasti; J Paul Chapple; Michaela Egertová; Maurice R Elphick; Michael E Cheetham; Louise A Metherell; Adrian J L Clark
Journal:  Proc Natl Acad Sci U S A       Date:  2009-03-27       Impact factor: 11.205

6.  The majority of adrenocorticotropin receptor (melanocortin 2 receptor) mutations found in familial glucocorticoid deficiency type 1 lead to defective trafficking of the receptor to the cell surface.

Authors:  T T Chung; T R Webb; L F Chan; S N Cooray; L A Metherell; P J King; J P Chapple; A J L Clark
Journal:  J Clin Endocrinol Metab       Date:  2008-10-07       Impact factor: 5.958

7.  Distinct melanocortin 2 receptor accessory protein domains are required for melanocortin 2 receptor interaction and promotion of receptor trafficking.

Authors:  Tom R Webb; Li Chan; Sadani N Cooray; Michael E Cheetham; J Paul Chapple; Adrian J L Clark
Journal:  Endocrinology       Date:  2008-09-25       Impact factor: 4.736

8.  Observations on the evolution of the melanocortin receptor gene family: distinctive features of the melanocortin-2 receptor.

Authors:  Robert M Dores
Journal:  Front Neurosci       Date:  2013-04-10       Impact factor: 4.677

9.  Hypothesis and Theory: Revisiting Views on the Co-evolution of the Melanocortin Receptors and the Accessory Proteins, MRAP1 and MRAP2.

Authors:  Robert M Dores
Journal:  Front Endocrinol (Lausanne)       Date:  2016-06-28       Impact factor: 5.555
  9 in total

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