OBJECTIVE: To study the effects of sodium usnic acid on proliferation of fibroblasts and skin wound healing. METHODS: L929 fibroblasts were incubated in culture medium containing sodium usnic acid, the proliferation of fibroblasts were measured by MTT. Skin wound healing promoting action of sodium usnic acid was determined in rats. RESULTS: Sodium usnic acid does not showed proliferation-promoting activity for L929 fibroblasts, sodium usnic acid by external application accelerated healing of rat backskin wound. The wound-healing rate of sodium usnic acid was higher than that of the control group at the 2th - 12th day after treatment. CONCLUSION: Sodium usnic acid can accelerate skin wound healing, the effects was not by stimulating proliferation of fibroblasts.
OBJECTIVE: To study the effects of sodium usnic acid on proliferation of fibroblasts and skin wound healing. METHODS: L929 fibroblasts were incubated in culture medium containing sodium usnic acid, the proliferation of fibroblasts were measured by MTT. Skin wound healing promoting action of sodium usnic acid was determined in rats. RESULTS:Sodium usnic acid does not showed proliferation-promoting activity for L929 fibroblasts, sodium usnic acid by external application accelerated healing of rat backskin wound. The wound-healing rate of sodium usnic acid was higher than that of the control group at the 2th - 12th day after treatment. CONCLUSION:Sodium usnic acid can accelerate skin wound healing, the effects was not by stimulating proliferation of fibroblasts.
Authors: Paula S Nunes; Ricardo L C Albuquerque; Danielle R R Cavalcante; Marx D M Dantas; Juliana C Cardoso; Marília S Bezerra; Jamille C C Souza; Mairim Russo Serafini; Lucindo J Quitans; Leonardo R Bonjardim; Adriano A S Araújo Journal: J Biomed Biotechnol Date: 2011-01-11