Literature DB >> 15981592

FTIR spectroscopic imaging of dissolution of a solid dispersion of nifedipine in poly(ethylene glycol).

K L Andrew Chan1, Sergei G Kazarian.   

Abstract

FTIR imaging was applied to study solid dispersions of a poorly water-soluble drug in poly(ethylene glycol) (PEG) and dissolution in water. It has been shown that initially amorphous nifedipine crystallizes within PEG-8000 for formulations with a drug loading of at least 10 wt%. The formation of a significant amount of crystalline drug within the polymer matrix reduces the rate of dissolution of the drug. This FTIR spectroscopic imaging in the ATR mode provides novel insight into the mechanism of dissolution of nifedipine from solid dispersions in water-soluble polymers, which is valuable in optimization of manufacturing these formulations.

Entities:  

Mesh：

Substances：

Year:  2004        PMID： 15981592     DOI： 10.1021/mp049973m

Source DB:  PubMed          Journal:  Mol Pharm        ISSN： 1543-8384            Impact factor:   4.939


  7 in total

1.  Effect of physical state and particle size distribution on dissolution enhancement of nimodipine/PEG solid dispersions prepared by melt mixing and solvent evaporation.

Authors:  George Z Papageorgiou; Dimitrios Bikiaris; Evagelos Karavas; Stavros Politis; Aristides Docoslis; Yong Park; Anagnostis Stergiou; Emmanouel Georgarakis
Journal:  AAPS J       Date:  2006-10-06       Impact factor: 4.009

2.  Characterization of the distribution, polymorphism, and stability of nimodipine in its solid dispersions in polyethylene glycol by micro-Raman spectroscopy and powder X-ray diffraction.

Authors:  Aristides Docoslis; Krista L Huszarik; George Z Papageorgiou; Dimitrios Bikiaris; Dimitrios Stergiou; E Georgarakis
Journal:  AAPS J       Date:  2007-12-07       Impact factor: 4.009

3.  Attenuated total reflection-Fourier transform infrared spectroscopic imaging of pharmaceuticals in microfluidic devices.

Authors:  Andrew V Ewing; Graham S Clarke; Sergei G Kazarian
Journal:  Biomicrofluidics       Date:  2016-04-20       Impact factor: 2.800

4.  Application of fiber-optic attenuated total reflection-FT-IR methods for in situ characterization of protein delivery systems in real time.

Authors:  Cathryn L McFearin; Jagadis Sankaranarayanan; Adah Almutairi
Journal:  Anal Chem       Date:  2011-04-20       Impact factor: 6.986

5.  Paclitaxel distribution in poly(ethylene glycol)/poly(lactide-co-glycolic acid) blends and its release visualized by coherent anti-Stokes Raman scattering microscopy.

Authors:  Eunah Kang; Joshua Robinson; Kinam Park; Ji-Xin Cheng
Journal:  J Control Release       Date:  2007-05-17       Impact factor: 9.776

6.  Investigating the Dissolution Performance of Amorphous Solid Dispersions Using Magnetic Resonance Imaging and Proton NMR.

Authors:  Francesco Tres; Steven R Coombes; Andrew R Phillips; Leslie P Hughes; Stephen A C Wren; Jonathan W Aylott; Jonathan C Burley
Journal:  Molecules       Date:  2015-09-10       Impact factor: 4.411

7.  Solid Dispersion Approach Improving Dissolution Rate of Stiripentol: a Novel Antiepileptic Drug.

Authors:  Samar Afifi
Journal:  Iran J Pharm Res       Date:  2015       Impact factor: 1.696
  7 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.