Literature DB >> 15981463

Modulation of Rho GTPases and the actin cytoskeleton by YopT of Yersinia.

M Aepfelbacher1, R Zumbihl, J Heesemann.   

Abstract

Pathogenic Yersinia species evade the innate cellular immune response by injecting antihost effector proteins (Yersinia outer proteins, Yops) into host cells through a type III secretion (TTS) apparatus. One of the six effector Yops, YopT, inactivates the small GTPase RhoA by removing the geranylgeranylated C-terminal cysteine. This cleavage results in release of RhoA from the cell membrane and subsequently in blockage of stress fiber formation. Thus YopT impairs cellular functions associated with cytoskeleton rearrangements.

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Year:  2005        PMID： 15981463     DOI： 10.1007/3-540-27511-8_9

Source DB:  PubMed          Journal:  Curr Top Microbiol Immunol        ISSN： 0070-217X            Impact factor:   4.291


  10 in total

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5.  Comparative Analyses of Transcriptional Profiles in Mouse Organs Using a Pneumonic Plague Model after Infection with Wild-Type Yersinia pestis CO92 and Its Braun Lipoprotein Mutant.

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6.  The responses of lungs and adjacent lymph nodes in responding to Yersinia pestis infection: A transcriptomic study using a non-human primate model.

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7.  In Silico Molecular Characterization of Cysteine Protease YopT from Yersinia pestis by Homology Modeling and Binding Site Identification.

Authors:  Md Anayet Hasan; S M Alauddin; Mohammad Al Amin; Suza Mohammad Nur; Adnan Mannan
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Review 9.  Molecular mechanisms of host cytoskeletal rearrangements by Shigella invasins.

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  10 in total

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