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Literature DB >> 15981416

A novel aspochalasin with HIV-1 integrase inhibitory activity from Aspergillus flavipes.

Simone Rochfort¹, Joanne Ford, Simon Ovenden, Soo San Wan, Samantha George, Howard Wildman, R Murray Tait, Barbara Meurer-Grimes, Susan Cox, Jonathan Coates, David Rhodes.

Abstract

A novel aspochalasin, aspochalasin L (1), was isolated from the fermentation broth of a soil-derived fungal culture identified as Aspergillus flavipes (Deuteromycota). Structure elucidation of 1 was accomplished by detailed spectroscopic data analyses and by comparison with related cytochalasins. Aspochalasin L demonstrated activity against HIV integrase with an IC50 of 71.7microM.

Entities: Chemical Species

Mesh：

Substances：

Year: 2005 PMID： 15981416 DOI： 10.1038/ja.2005.34

Source DB: PubMed Journal: J Antibiot (Tokyo) ISSN： 0021-8820 Impact factor: 2.649

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Cited

13 in total

1. Optimized production and isolation of antibacterial agent from marine Aspergillus flavipes against Vibrio harveyi.

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Journal: Acta Crystallogr Sect E Struct Rep Online Date: 2010-07-31

3. Phylogenetic identification of fungi isolated from the marine sponge Tethya aurantium and identification of their secondary metabolites.

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4. New meroterpenoids from the endophytic fungus Aspergillus flavipes AIL8 derived from the mangrove plant Acanthus ilicifolius.

Authors: Zhi-Qiang Bai; Xiuping Lin; Junfeng Wang; Xuefeng Zhou; Juan Liu; Bin Yang; Xianwen Yang; Shengrong Liao; Lishu Wang; Yonghong Liu
Journal: Mar Drugs Date: 2015-01-07 Impact factor: 5.118

A novel aspochalasin with HIV-1 integrase inhibitory activity from Aspergillus flavipes.

1. Optimized production and isolation of antibacterial agent from marine Aspergillus flavipes against Vibrio harveyi.

2. Ep-oxy-cytochalasin H methanol solvate.

3. Phylogenetic identification of fungi isolated from the marine sponge Tethya aurantium and identification of their secondary metabolites.

4. New meroterpenoids from the endophytic fungus Aspergillus flavipes AIL8 derived from the mangrove plant Acanthus ilicifolius.

5. Methylthio-aspochalasins from a marine-derived fungus Aspergillus sp.

6. Flavichalasines A-M, cytochalasan alkaloids from Aspergillus flavipes.

Review 7. Potential of small-molecule fungal metabolites in antiviral chemotherapy.

8. Nine new cytochalasan alkaloids from Chaetomium globosum TW1-1 (Ascomycota, Sordariales).

9. Transcriptional and Proteomic Profiling of Aspergillus flavipes in Response to Sulfur Starvation.

Review 10. Investigation of the Anti-Prostate Cancer Properties of Marine-Derived Compounds.