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Literature DB >> 15980400

Induction of telithromycin resistance by erythromycin in isolates of macrolide-resistant Staphylococcus spp.

Kepler A Davis¹, Sharon A Crawford, Kristin R Fiebelkorn, James H Jorgensen.

Abstract

Staphylococcal isolates were examined for possible macrolide-inducible resistance to telithromycin. All macrolide-resistant isolates demonstrated telithromycin D-shaped zones. This result did not discriminate between resistance due to an efflux mechanism (msrA) or a ribosomal target modification (ermA or ermC). Inducible telithromycin resistance in staphylococci does not appear to be analogous to inducible clindamycin resistance.

Entities: Chemical Gene

Mesh：

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Year: 2005 PMID： 15980400 PMCID： PMC1168692 DOI： 10.1128/AAC.49.7.3059-3061.2005

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

15 in total

1. Cloning and sequences of inducible and constitutive macrolide resistance genes in Staphylococcus aureus that correspond to an ABC transporter.

Authors: M Matsuoka; L Jánosi; K Endou; Y Nakajima
Journal: FEMS Microbiol Lett Date: 1999-12-01 Impact factor: 2.742

2. Should clindamycin be used in treatment of patients with infections caused by erythromycin-resistant staphylococci?

Authors: G G Rao
Journal: J Antimicrob Chemother Date: 2000-05 Impact factor: 5.790

3. Patterns of phenotypic resistance to the macrolide-lincosamide-ketolide-streptogramin group of antibiotics in staphylococci.

Authors: J M Hamilton-Miller; S Shah
Journal: J Antimicrob Chemother Date: 2000-12 Impact factor: 5.790

4. In vitro activity of telithromycin and quinupristin/dalfopristin against methicillin-resistant coagulase-negative staphylococci with defined resistance genotypes.

Authors: G Novotná; J Spízek; J Janata
Journal: Folia Microbiol (Praha) Date: 2007 Impact factor: 2.629

4 in total

Induction of telithromycin resistance by erythromycin in isolates of macrolide-resistant Staphylococcus spp.

1. Cloning and sequences of inducible and constitutive macrolide resistance genes in Staphylococcus aureus that correspond to an ABC transporter.

2. Should clindamycin be used in treatment of patients with infections caused by erythromycin-resistant staphylococci?

3. Patterns of phenotypic resistance to the macrolide-lincosamide-ketolide-streptogramin group of antibiotics in staphylococci.

4. Multiple novel inhibitors of the NorA multidrug transporter of Staphylococcus aureus.

Review 5. Structure-activity relationships of ketolides vs. macrolides.

6. Clindamycin treatment of Staphylococcus aureus expressing inducible clindamycin resistance.

Review 7. Drugs of the 21st century: telithromycin (HMR 3647)--the first ketolide.

Review 8. Ketolides-telithromycin, an example of a new class of antibacterial agents.

9. A novel inhibitor of multidrug efflux pumps in Staphylococcus aureus.

10. Clindamycin treatment of methicillin-resistant Staphylococcus aureus infections in children.

1. CEM-101 activity against Gram-positive organisms.

Review 2. Modes and modulations of antibiotic resistance gene expression.

Review 3. Acquired inducible antimicrobial resistance in Gram-positive bacteria.

4. In vitro activity of telithromycin and quinupristin/dalfopristin against methicillin-resistant coagulase-negative staphylococci with defined resistance genotypes.