Literature DB >> 15980387

Time-kill study of the activity of telithromycin against macrolide-resistant Streptococcus pneumoniae Isolates with 23S rRNA mutations and changes in ribosomal proteins L4 and L22.

Ralf René Reinert1, Adnan Al-Lahham.   

Abstract

By use of a time-kill methodology, the antipneumococcal activity of telithromycin was determined against macrolide-resistant S. pneumoniae isolates having mutations in the 23S rRNA gene and changes in the ribosomal proteins L4 and L22. Telithromycin had MICs ranging between 0.03 and 0.25 microg/ml and was bactericidal against four of seven strains after 24 h at two times the MIC.

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Year:  2005        PMID： 15980387      PMCID： PMC1168645          DOI： 10.1128/AAC.49.7.3011-3013.2005

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  13 in total

1.  Emergence of macrolide resistance during treatment of pneumococcal pneumonia.

Authors:  Daniel M Musher; Mark E Dowell; Virginia D Shortridge; Robert K Flamm; James H Jorgensen; Pierre Le Magueres; Kurt L Krause
Journal:  N Engl J Med       Date:  2002-02-21       Impact factor: 91.245

2.  In vitro activities of novel 2-fluoro-naphthyridine-containing ketolides.

Authors:  Darren Abbanat; Glenda Webb; Barbara Foleno; Y Li; Mark Macielag; Deborah Montenegro; Ellyn Wira; Karen Bush
Journal:  Antimicrob Agents Chemother       Date:  2005-01       Impact factor: 5.191

3.  Emergence of macrolide and penicillin resistance among invasive pneumococcal isolates in Germany.

Authors:  Ralf René Reinert; Adnan Al-Lahham; Maria Lemperle; Christoph Tenholte; Claudia Briefs; Stefan Haupts; Hans Hubert Gerards; Rudolf Lütticken
Journal:  J Antimicrob Chemother       Date:  2002-01       Impact factor: 5.790

4.  Macrolide resistance among invasive Streptococcus pneumoniae isolates.

Authors:  T B Hyde; K Gay; D S Stephens; D J Vugia; M Pass; S Johnson; N L Barrett; W Schaffner; P R Cieslak; P S Maupin; E R Zell; J H Jorgensen; R R Facklam; C G Whitney
Journal:  JAMA       Date:  2001-10-17       Impact factor: 56.272

5.  Study of comparative antipneumococcal activities of penicillin G, RP 59500, erythromycin, sparfloxacin, ciprofloxacin, and vancomycin by using time-kill methodology.

Authors:  G A Pankuch; M R Jacobs; P C Appelbaum
Journal:  Antimicrob Agents Chemother       Date:  1994-09       Impact factor: 5.191

6.  Susceptibilities to telithromycin and six other agents and prevalence of macrolide resistance due to L4 ribosomal protein mutation among 992 Pneumococci from 10 central and Eastern European countries.

Authors:  Kensuke Nagai; Peter C Appelbaum; Todd A Davies; Linda M Kelly; Dianne B Hoellman; Arjana Tambic Andrasevic; Liga Drukalska; Waleria Hryniewicz; Michael R Jacobs; Jana Kolman; Jolanta Miciuleviciene; Marina Pana; Lena Setchanova; Marianne Konkoly Thege; Helena Hupkova; Jan Trupl; Pavla Urbaskova
Journal:  Antimicrob Agents Chemother       Date:  2002-02       Impact factor: 5.191

7.  Mutations in 23S rRNA and ribosomal protein L4 account for resistance in pneumococcal strains selected in vitro by macrolide passage.

Authors:  A Tait-Kamradt; T Davies; M Cronan; M R Jacobs; P C Appelbaum; J Sutcliffe
Journal:  Antimicrob Agents Chemother       Date:  2000-08       Impact factor: 5.191

Review 8.  Clinical efficacy of ketolides in the treatment of respiratory tract infections.

Authors:  Ralf René Reinert
Journal:  J Antimicrob Chemother       Date:  2004-04-29       Impact factor: 5.790

9.  Streptococcus pneumoniae and Streptococcus pyogenes resistant to macrolides but sensitive to clindamycin: a common resistance pattern mediated by an efflux system.

Authors:  J Sutcliffe; A Tait-Kamradt; L Wondrack
Journal:  Antimicrob Agents Chemother       Date:  1996-08       Impact factor: 5.191

10.  Macrolide-resistant Streptococcus pneumoniae and Streptococcus pyogenes in the pediatric population in Germany during 2000-2001.

Authors:  Ralf René Reinert; Rudolf Lütticken; André Bryskier; Adnan Al-Lahham
Journal:  Antimicrob Agents Chemother       Date:  2003-02       Impact factor: 5.191
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  1 in total

Review 1.  Ketolides--the modern relatives of macrolides : the pharmacokinetic perspective.

Authors:  Markus Zeitlinger; Claudia Christina Wagner; Birgit Heinisch
Journal:  Clin Pharmacokinet       Date:  2009       Impact factor: 6.447
  1 in total

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