| Literature DB >> 15979783 |
Ashleigh Hill1, Suzanne McFarlane, Patrick G Johnston, David J J Waugh.
Abstract
The hyaluronan (HA) receptor CD44 has a well documented role in tumour metastasis. This review focuses on the potential significance of CD44 expression and function in regulating the metastasis of both haematological malignancies and solid tumours to the bone. Specifically, the review will discuss the evidence that HA-CD44 interactions facilitate the arrest of circulating malignant cells upon the bone marrow endothelial cells and discuss data that suggests CD44 may orchestrate the ability of tumour cells to regulate the modification of the bone matrix and support its colonisation by malignant cells.Entities:
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Year: 2005 PMID： 15979783 DOI： 10.1016/j.canlet.2005.05.006
Source DB: PubMed Journal: Cancer Lett ISSN： 0304-3835 Impact factor: 8.679