| Literature DB >> 15979380 |
Hidetsugu Tsujigiwa1, Hitoshi Nagatsuka, Phuu Pwint Han, Mehmet Gunduz, Chong Huat Siar, Shinichiro Oida, Noriyuki Nagai.
Abstract
Although the amelogenin gene is expressed in ameloblastoma, the precise expression pattern of X and Y amelogenin genes (AMGX, AMGY) in this tumor has not yet been identified. In this study, we analyzed amelogenin gene expression in 19 samples (9 male, 10 female) of oral ameloblastomas by RT-PCR and detect the chromosomal origin of amelogenin mRNA by restriction enzyme digestion of the RT-PCR product. All tumor samples expressed amelogenin mRNA. We could detect increased level of AMGY expression in all male samples, higher than that of AMEX. It is an interesting finding as in normal male tooth development, the expression of AMGY is very much lower than that of AMGX. We postulate that epigenetic change of sex chromosomes may have some correlations with tumorigenesis of ameloblastoma. We also discuss the other possible mechanisms and points for future studies on this change in expression pattern.Entities:
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Year: 2005 PMID： 15979380 DOI： 10.1016/j.oraloncology.2005.04.005
Source DB: PubMed Journal: Oral Oncol ISSN： 1368-8375 Impact factor: 5.337