BACKGROUND AND AIM: The aim of this randomized double blind placebo controlled study was to investigate the effectiveness and the safety of venlafaxine XR 75 and 150 mg on ongoing pain and on quantitative sensory tests in 60 patients with neuropathic pain for 8 weeks. METHODS: Evaluation parameters consisted of ongoing pain intensity (VAS), patient satisfaction, side effects, global efficacy and tolerance. Quantitative sensory measurements taken from the affected area before and after the drug treatment included pin-prick hyperalgesia, allodynia, detection and pain thresholds to electrical and heat stimuli, temporal summation of repetitive electrical and heat stimuli. RESULTS: A total of 55 patients completed the study. VAS scores decreased significantly compared to the baseline measurements in all groups. There was no significant difference between the groups regarding pain intensity and escape medication. The areas of allodynia and pin-prick hyperalgesia decreased significantly in venlafaxine groups compared to the placebo. There was no significant difference between the groups regarding the detection thresholds (electrical and heat). The pain threshold and the summation threshold to electrical stimuli and the summation threshold to heat stimuli increased significantly following treatment in both venlafaxine groups. In addition, the degree of the temporal summation to electrical and heat stimuli decreased significantly following treatment in both venlafaxine groups compared to the placebo. CONCLUSION: The study showed significant effect of venlafaxine in the manifestations of hyperalgesia and temporal summation, but not on the ongoing pain intensity. Furthermore, the quantitative sensory tests provided complementing information to the clinical measures.
RCT Entities:
BACKGROUND AND AIM: The aim of this randomized double blind placebo controlled study was to investigate the effectiveness and the safety of venlafaxine XR 75 and 150 mg on ongoing pain and on quantitative sensory tests in 60 patients with neuropathic pain for 8 weeks. METHODS: Evaluation parameters consisted of ongoing pain intensity (VAS), patient satisfaction, side effects, global efficacy and tolerance. Quantitative sensory measurements taken from the affected area before and after the drug treatment included pin-prick hyperalgesia, allodynia, detection and pain thresholds to electrical and heat stimuli, temporal summation of repetitive electrical and heat stimuli. RESULTS: A total of 55 patients completed the study. VAS scores decreased significantly compared to the baseline measurements in all groups. There was no significant difference between the groups regarding pain intensity and escape medication. The areas of allodynia and pin-prick hyperalgesia decreased significantly in venlafaxine groups compared to the placebo. There was no significant difference between the groups regarding the detection thresholds (electrical and heat). The pain threshold and the summation threshold to electrical stimuli and the summation threshold to heat stimuli increased significantly following treatment in both venlafaxine groups. In addition, the degree of the temporal summation to electrical and heat stimuli decreased significantly following treatment in both venlafaxine groups compared to the placebo. CONCLUSION: The study showed significant effect of venlafaxine in the manifestations of hyperalgesia and temporal summation, but not on the ongoing pain intensity. Furthermore, the quantitative sensory tests provided complementing information to the clinical measures.
Authors: Nicolas Dreyfus; Jason K Myers; Valentina O Badescu; Oscar de Frutos; Maria Luz de la Puente; Chunjin Ding; Sandra A Filla; Karsten Fynboe; Douglas L Gernert; Beverly A Heinz; Susan K Hemrick-Luecke; Kirk W Johnson; Michael P Johnson; Pilar López; Patrick L Love; Laura J Martin; Thierry Masquelin; Michael J McCoy; Javier Mendiola; Denise Morrow; Mark Muhlhauser; Gustavo Pascual; Thomas J Perun; Lance A Pfeifer; Lee A Phebus; Simon J Richards; Juan Antonio Rincón; Eric P Seest; Jikesh Shah; Jia Shaojuan; Rosa Maria A Simmons; Gregory A Stephenson; Eric G Tromiczak; Linda K Thompson; Magnus W Walter; Wayne W Weber; Hamideh Zarrinmayeh; Craig E Thomas; Elizabeth Joshi; Smriti Iyengar; Anette M Johansson Journal: ACS Med Chem Lett Date: 2013-05-07 Impact factor: 4.345
Authors: Stefan Begré; Martin Traber; Martin Gerber; Roland von Känel Journal: Soc Psychiatry Psychiatr Epidemiol Date: 2009-03-20 Impact factor: 4.328
Authors: Carina Riediger; Tibor Schuster; Kristian Barlinn; Sarah Maier; Jürgen Weitz; Timo Siepmann Journal: Front Neurol Date: 2017-07-14 Impact factor: 4.003