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Literature DB >> 15978805

Neuroprotective effects of naturally occurring biflavonoids.

Sam Sik Kang¹, Ji Yeon Lee, Yoo Keum Choi, Sun Sook Song, Ju Sun Kim, Su Jin Jeon, Yong Nam Han, Kun Ho Son, Byung Hee Han.

Abstract

We examined neuroprotective effects of naturally occurring biflavonoids on oxidative stress-induced and amyloid beta peptide-induced cell death in neuronal cells. Among the nine biflavonoids tested, amentoflavone, ginkgetin, and isoginkgetin exhibited strong neuroprotection against cytotoxic insults induced by oxidative stress and amyloid beta, suggesting their therapeutic potential against neurodegenerative diseases, including ischemic stroke and Alzheimer's disease.

Entities: Chemical Disease Gene

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Year: 2005 PMID： 15978805 DOI： 10.1016/j.bmcl.2005.05.078

Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823

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Cited

23 in total

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Review 2. Targeting NADPH oxidase and phospholipases A2 in Alzheimer's disease.

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5. Cognition Enhancing Activity of Sulforaphane Against Scopolamine Induced Cognitive Impairment in Zebra Fish (Danio rerio).

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6. The flavonoid derivative 2-(4' Benzyloxyphenyl)-3-hydroxy-chromen-4-one protects against Aβ42-induced neurodegeneration in transgenic Drosophila: insights from in silico and in vivo studies.

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Journal: Neurotox Res Date: 2014-04-05 Impact factor: 3.911

Neuroprotective effects of naturally occurring biflavonoids.

1. The Neuroprotective Effect of Syringic Acid on Spinal Cord Ischemia/Reperfusion Injury in Rats.

Review 2. Targeting NADPH oxidase and phospholipases A2 in Alzheimer's disease.

Review 3. Hybrids: a new paradigm to treat Alzheimer's disease.

4. Neuroprotective effects of ugonin K on hydrogen peroxide-induced cell death in human neuroblastoma SH-SY5Y cells.

5. Cognition Enhancing Activity of Sulforaphane Against Scopolamine Induced Cognitive Impairment in Zebra Fish (Danio rerio).

6. The flavonoid derivative 2-(4' Benzyloxyphenyl)-3-hydroxy-chromen-4-one protects against Aβ42-induced neurodegeneration in transgenic Drosophila: insights from in silico and in vivo studies.

7. Amentoflavone: A Bifunctional Metal Chelator that Controls the Formation of Neurotoxic Soluble Aβ₄₂ Oligomers.

8. Naturally Occurring Cytotoxic [3'→8″]-Biflavonoids from Podocarpus nakaii.

9. The biflavonoid isoginkgetin is a general inhibitor of Pre-mRNA splicing.

10. Amentoflavone protects hippocampal neurons: anti-inflammatory, antioxidative, and antiapoptotic effects.