| Literature DB >> 15977324 |
Ken Kasahara1, Shinkichi Nomura, Hideyuki Matsuura, Masahiro Yamasaki, Osamu Yamato, Yoshimitsu Maede, Ken Katakura, Mamoru Suzuki, Teruhiko Yoshihara.
Abstract
Anti-babesial activity was confirmed in an extract of the bark of Curcuma zedoaria. The active ingredients were isolated, and their chemical structures were determined to be zedoalactones A, B, and C based on spectral data. Zedoalactone C is a hitherto unreported compound. The IC50 vales of these active compounds against Babesia gibsoni were compared with a standard drug, diminazene aceturate. The IC50 value of diminazene aceturate was 0.6 microg/mL, while those of zedoalactones A, B, and C were 16.5, 1.6 and 4.2 microg/mL, respectively.Entities:
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Year: 2005 PMID： 15977324 DOI： 10.1055/s-2005-871216
Source DB: PubMed Journal: Planta Med ISSN： 0032-0943 Impact factor: 3.352