BACKGROUND: Experimental evidence suggests that lung cancer development and progression can be linked to an increased proliferation rate. AIMS/ METHODS: To evaluate the immunohistochemical expression of seven components of the cell cycle machinery in a series of well characterised non-small cell lung cancer (NSCLC) specimens (n = 105). RESULTS: Multivariate analysis revealed that simultaneous loss of expression of three of these factors--cyclin D1, the cyclin dependent kinase inhibitor p16, and the tumour suppressor retinoblastoma protein Rb2/p130--correlated with survival, confirming the hypothesis that the cyclin D1-p16-retinoblastoma tumour suppressor pathway is inactivated in most lung cancer samples. CONCLUSIONS: These results suggest that loss of control of cell cycle checkpoints is a common occurrence in lung cancer and support the idea that functional cooperation between different cell cycle regulatory proteins constitutes another level of regulation in cell growth control and tumour suppression.
BACKGROUND: Experimental evidence suggests that lung cancer development and progression can be linked to an increased proliferation rate. AIMS/ METHODS: To evaluate the immunohistochemical expression of seven components of the cell cycle machinery in a series of well characterised non-small cell lung cancer (NSCLC) specimens (n = 105). RESULTS: Multivariate analysis revealed that simultaneous loss of expression of three of these factors--cyclin D1, the cyclin dependent kinase inhibitor p16, and the tumour suppressor retinoblastoma protein Rb2/p130--correlated with survival, confirming the hypothesis that the cyclin D1-p16-retinoblastoma tumour suppressor pathway is inactivated in most lung cancer samples. CONCLUSIONS: These results suggest that loss of control of cell cycle checkpoints is a common occurrence in lung cancer and support the idea that functional cooperation between different cell cycle regulatory proteins constitutes another level of regulation in cell growth control and tumour suppression.
Authors: T K Zirbes; S E Baldus; S P Moenig; S Nolden; D Kunze; S T Shafizadeh; P M Schneider; J Thiele; A H Hoelscher; H P Dienes Journal: Int J Cancer Date: 2000-01-20 Impact factor: 7.396
Authors: A M Groeger; M Caputi; V Esposito; A De Luca; L Bagella; C Pacilio; W Klepetko; G G Giordano; F Baldi; H E Kaiser; E Wolner; A Giordano Journal: J Thorac Cardiovasc Surg Date: 1999-09 Impact factor: 5.209
Authors: Ana María Gómez; Jose Ramón Jarabo Sarceda; Jose Antonio L García-Asenjo; Cristina Fernandez; Susana Hernandez; Julian Sanz; Elena Fernandez; Joaquin Calatayud; Antonio Torres; Florentino Hernando Journal: Tumour Biol Date: 2014-01-19
Authors: Mara Campioni; Vincenzo Ambrogi; Eugenio Pompeo; Gennaro Citro; Mauro Castelli; Enrico P Spugnini; Antonio Gatti; Pierluigi Cardelli; Laura Lorenzon; Alfonso Baldi; Tommaso C Mineo Journal: J Exp Clin Cancer Res Date: 2008-09-15