BACKGROUND: Although white blood cell (WBC) count has been consistently associated with cardiovascular end points, little information is available on the independent contribution of specific white blood cell types. The objective of this study is to assess the independent association of WBC types and other inflammatory markers with the presence of reduced ankle-brachial blood pressure index (ABI), a marker of subclinical peripheral arterial disease (PAD). METHODS & RESULTS: Cross-sectional study in 3949 individuals > or =40 years of age without known cardiovascular disease who participated in the 1999 to 2002 National Health and Nutrition Examination Survey (NHANES). PAD was defined as an ABI <0.9 in at least 1 leg. After adjustment for traditional cardiovascular risk factors, the odds ratios of PAD comparing the highest to the lowest quartiles were 2.24 (95% confidence interval 1.24 to 4.04) for monocytes, 1.74 (0.87 to 3.45) for neutrophils, 2.53 (1.62 to 3.96) for C-reactive protein, and 2.68 (1.03 to 6.94) for fibrinogen. When WBC types and inflammatory markers were simultaneously included in the full model, the corresponding odds ratios were 1.91 (95% confidence interval 1.06 to 3.42) for monocytes, 1.15 (0.49 to 2.69) for neutrophils, 1.37 (0.75 to 2.49) for C-reactive protein, and 2.21 (0.88 to 5.57) for fibrinogen. CONCLUSIONS: Monocytes were the only WBC type significantly and independently associated with PAD in a representative sample of the U.S. population after adjustment for other inflammatory markers. These findings reflect the potential role of circulating monocyte counts as markers of atherosclerosis.
BACKGROUND: Although white blood cell (WBC) count has been consistently associated with cardiovascular end points, little information is available on the independent contribution of specific white blood cell types. The objective of this study is to assess the independent association of WBC types and other inflammatory markers with the presence of reduced ankle-brachial blood pressure index (ABI), a marker of subclinical peripheral arterial disease (PAD). METHODS & RESULTS: Cross-sectional study in 3949 individuals > or =40 years of age without known cardiovascular disease who participated in the 1999 to 2002 National Health and Nutrition Examination Survey (NHANES). PAD was defined as an ABI <0.9 in at least 1 leg. After adjustment for traditional cardiovascular risk factors, the odds ratios of PAD comparing the highest to the lowest quartiles were 2.24 (95% confidence interval 1.24 to 4.04) for monocytes, 1.74 (0.87 to 3.45) for neutrophils, 2.53 (1.62 to 3.96) for C-reactive protein, and 2.68 (1.03 to 6.94) for fibrinogen. When WBC types and inflammatory markers were simultaneously included in the full model, the corresponding odds ratios were 1.91 (95% confidence interval 1.06 to 3.42) for monocytes, 1.15 (0.49 to 2.69) for neutrophils, 1.37 (0.75 to 2.49) for C-reactive protein, and 2.21 (0.88 to 5.57) for fibrinogen. CONCLUSIONS: Monocytes were the only WBC type significantly and independently associated with PAD in a representative sample of the U.S. population after adjustment for other inflammatory markers. These findings reflect the potential role of circulating monocyte counts as markers of atherosclerosis.
Authors: Bart Lammers; Prakash G Chandak; Elma Aflaki; Gijs H M Van Puijvelde; Branislav Radovic; Reeni B Hildebrand; Illiana Meurs; Ruud Out; Johan Kuiper; Theo J C Van Berkel; Dagmar Kolb; Guenter Haemmerle; Rudolf Zechner; Sanja Levak-Frank; Miranda Van Eck; Dagmar Kratky Journal: Arterioscler Thromb Vasc Biol Date: 2010-10-28 Impact factor: 8.311
Authors: Jesse W Williams; Andrew Elvington; Stoyan Ivanov; Skyler Kessler; Hannah Luehmann; Osamu Baba; Brian T Saunders; Ki-Wook Kim; Michael W Johnson; Clarissa S Craft; Jae-Hoon Choi; Mary G Sorci-Thomas; Bernd H Zinselmeyer; Jonathan R Brestoff; Yongjian Liu; Gwendalyn J Randolph Journal: Circ Res Date: 2017-07-10 Impact factor: 17.367
Authors: Faisal A Arain; Mahyar Khaleghi; Kent R Bailey; Brian D Lahr; Thom W Rooke; Iftikhar J Kullo Journal: Am J Med Date: 2009-09 Impact factor: 4.965