| Literature DB >> 15975799 |
Silvia Selleri1, Paola Gratteri, Camilla Costagli, Claudia Bonaccini, Annarella Costanzo, Fabrizio Melani, Gabriella Guerrini, Giovanna Ciciani, Barbara Costa, Francesca Spinetti, Claudia Martini, Fabrizio Bruni.
Abstract
The present paper reports the synthesis and binding studies of new 2-phenylpyrazolo[1,5-a]pyrimidin-3-yl acetamides as selective Peripheral Benzodiazepine Receptor (PBR) ligands. The variability of substituents at the 3-position was investigated and a 3D-QSAR model was proposed to evaluate the effect of different substitutions on the acetamide moiety. In addition, a subset of the novel compounds showing high affinity for PBR was tested for their ability to modulate the steroid biosynthesis in C6 glioma cells.Entities:
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Year: 2005 PMID： 15975799 DOI： 10.1016/j.bmc.2005.05.015
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641