Literature DB >> 15974931

Allosterism at muscarinic receptors: ligands and mechanisms.

N J M Birdsall1, S Lazareno.   

Abstract

The evaluation of allosteric ligands at muscarinic receptors is discussed in terms of the ability of the experimental data to be interpreted by the allosteric ternary complex model. The compilation of useful SAR information of allosteric ligands is not simple, especially for muscarinic receptors, where there are multiple allosteric sites and complex interactions.

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Year:  2005        PMID： 15974931     DOI： 10.2174/1389557054023251

Source DB:  PubMed          Journal:  Mini Rev Med Chem        ISSN： 1389-5575            Impact factor:   3.862


  32 in total

1.  Mutagenesis of nucleophilic residues near the orthosteric binding pocket of M1 and M2 muscarinic receptors: effect on the binding of nitrogen mustard analogs of acetylcholine and McN-A-343.

Authors:  Hinako Suga; Gregory W Sawyer; Frederick J Ehlert
Journal:  Mol Pharmacol       Date:  2010-07-19       Impact factor: 4.436

2.  DFT calculation of four new potential agents muscarinic of bispyridinium type: structure, synthesis, biological activity, hydration, and relations with the potents W84 and DUO-3O.

Authors:  M Alcolea Palafox; P Posada-Moreno; A L Villarino-Marín; C Martinez-Rincon; I Ortuño-Soriano; I Zaragoza-García
Journal:  J Comput Aided Mol Des       Date:  2010-12-22       Impact factor: 3.686

3.  Structure-activity relationships of new 1H-imidazo[4,5-c]quinolin-4-amine derivatives as allosteric enhancers of the A3 adenosine receptor.

Authors:  Anikó Göblyös; Zhan-Guo Gao; Johannes Brussee; Roberto Connestari; Sabrina Neves Santiago; Kai Ye; Adriaan P Ijzerman; Kenneth A Jacobson
Journal:  J Med Chem       Date:  2006-06-01       Impact factor: 7.446

4.  Discovery of positive allosteric modulators and silent allosteric modulators of the μ-opioid receptor.

Authors:  Neil T Burford; Mary J Clark; Tom S Wehrman; Samuel W Gerritz; Martyn Banks; Jonathan O'Connell; John R Traynor; Andrew Alt
Journal:  Proc Natl Acad Sci U S A       Date:  2013-06-10       Impact factor: 11.205

5.  The second extracellular loop of the adenosine A1 receptor mediates activity of allosteric enhancers.

Authors:  Dylan P Kennedy; Fiona M McRobb; Susan A Leonhardt; Michael Purdy; Heidi Figler; Melissa A Marshall; Mahendra Chordia; Robert Figler; Joel Linden; Ruben Abagyan; Mark Yeager
Journal:  Mol Pharmacol       Date:  2013-11-11       Impact factor: 4.436

6.  Allosteric site in M2 acetylcholine receptors: evidence for a major conformational change upon binding of an orthosteric agonist instead of an antagonist.

Authors:  Maren Grossmüller; Johannes Antony; Christian Tränkle; Ulrike Holzgrabe; Klaus Mohr
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2005-12-16       Impact factor: 3.000

7.  A fluorescence resonance energy transfer-based M2 muscarinic receptor sensor reveals rapid kinetics of allosteric modulation.

Authors:  Monika Maier-Peuschel; Nadine Frölich; Christian Dees; Leif G Hommers; Carsten Hoffmann; Viacheslav O Nikolaev; Martin J Lohse
Journal:  J Biol Chem       Date:  2010-01-18       Impact factor: 5.157

8.  Isolation and pharmacological characterization of AdTx1, a natural peptide displaying specific insurmountable antagonism of the alpha1A-adrenoceptor.

Authors:  L Quinton; E Girard; A Maiga; M Rekik; P Lluel; G Masuyer; M Larregola; C Marquer; J Ciolek; T Magnin; R Wagner; J Molgó; R Thai; C Fruchart-Gaillard; G Mourier; J Chamot-Rooke; A Ménez; S Palea; D Servent; N Gilles
Journal:  Br J Pharmacol       Date:  2009-12-15       Impact factor: 8.739

Review 9.  Non-traditional roles of G protein-coupled receptors in basic cell biology.

Authors:  Xin Zhang; Ulrike S Eggert
Journal:  Mol Biosyst       Date:  2013-04-05

Review 10.  Positive allosteric modulators of the μ-opioid receptor: a novel approach for future pain medications.

Authors:  N T Burford; J R Traynor; A Alt
Journal:  Br J Pharmacol       Date:  2014-07-01       Impact factor: 8.739
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