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Literature DB >> 15974909

A potential role of the curry spice curcumin in Alzheimer's disease.

John M Ringman¹, Sally A Frautschy, Gregory M Cole, Donna L Masterman, Jeffrey L Cummings.

Abstract

There is substantial in-vitro data indicating that curcumin has antioxidant, anti-inflammatory, and anti-amyloid activity. In addition, studies in animal models of Alzheimer's disease (AD) indicate a direct effect of curcumin in decreasing the amyloid pathology of AD. As the widespread use of curcumin as a food additive and relatively small short-term studies in humans suggest safety, curcumin is a promising agent in the treatment and/or prevention of AD. Nonetheless, important information regarding curcumin bioavailability, safety and tolerability, particularly in an elderly population is lacking. We are therefore performing a study of curcumin in patients with AD to gather this information in addition to data on the effect of curcumin on biomarkers of AD pathology.

Entities: Chemical Disease Species

Mesh：

Substances：
Curcumin

Year: 2005 PMID： 15974909 PMCID： PMC1702408 DOI： 10.2174/1567205053585882

Source DB: PubMed Journal: Curr Alzheimer Res ISSN： 1567-2050 Impact factor: 3.498

45 in total

1. Phenolic anti-inflammatory antioxidant reversal of Abeta-induced cognitive deficits and neuropathology.

Authors: S A Frautschy; W Hu; P Kim; S A Miller; T Chu; M E Harris-White; G M Cole
Journal: Neurobiol Aging Date: 2001 Nov-Dec Impact factor: 4.673

2. Strategy and planning for chemopreventive drug development: clinical development plans II.

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Review 3. Safety and anti-inflammatory activity of curcumin: a component of tumeric (Curcuma longa).

Authors: Nita Chainani-Wu
Journal: J Altern Complement Med Date: 2003-02 Impact factor: 2.579

4. Studies on spice principles as antioxidants in the inhibition of lipid peroxidation of rat liver microsomes.

Authors: A C Reddy; B R Lokesh
Journal: Mol Cell Biochem Date: 1992-04 Impact factor: 3.396

5. Incidence of Alzheimer's disease in a rural community in India: the Indo-US study.

Authors: V Chandra; R Pandav; H H Dodge; J M Johnston; S H Belle; S T DeKosky; M Ganguli
Journal: Neurology Date: 2001-09-25 Impact factor: 9.910

6. Inhibitory effect of curcumin, a food spice from turmeric, on platelet-activating factor- and arachidonic acid-mediated platelet aggregation through inhibition of thromboxane formation and Ca2+ signaling.

Authors: B H Shah; Z Nawaz; S A Pertani; A Roomi; H Mahmood; S A Saeed; A H Gilani
Journal: Biochem Pharmacol Date: 1999-10-01 Impact factor: 5.858

7. Evidence that increased hippocampal expression of the cytokine interleukin-1 beta is a common trigger for age- and stress-induced impairments in long-term potentiation.

Authors: C A Murray; M A Lynch
Journal: J Neurosci Date: 1998-04-15 Impact factor: 6.167

8. Curcumin, a major constituent of turmeric, corrects cystic fibrosis defects.

Authors: Marie E Egan; Marilyn Pearson; Scott A Weiner; Vanathy Rajendran; Daniel Rubin; Judith Glöckner-Pagel; Susan Canny; Kai Du; Gergely L Lukacs; Michael J Caplan
Journal: Science Date: 2004-04-23 Impact factor: 47.728

9. Evaluation of anti-inflammatory property of curcumin (diferuloyl methane) in patients with postoperative inflammation.

Authors: R R Satoskar; S J Shah; S G Shenoy
Journal: Int J Clin Pharmacol Ther Toxicol Date: 1986-12

10. Preliminary study on antirheumatic activity of curcumin (diferuloyl methane).

Authors: S D Deodhar; R Sethi; R C Srimal
Journal: Indian J Med Res Date: 1980-04 Impact factor: 2.375

123 in total

1. Induction of oxidative stress and inhibition of superoxide dismutase expression in rat cerebral cortex and cerebellum by PTU-induced hypothyroidism and its reversal by curcumin.

Authors: Srikanta Jena; Chinmay Anand; Gagan Bihari Nityananda Chainy; Jagneshwar Dandapat
Journal: Neurol Sci Date: 2011-11-11 Impact factor: 3.307

A potential role of the curry spice curcumin in Alzheimer's disease.

1. Phenolic anti-inflammatory antioxidant reversal of Abeta-induced cognitive deficits and neuropathology.

2. Strategy and planning for chemopreventive drug development: clinical development plans II.

Review 3. Safety and anti-inflammatory activity of curcumin: a component of tumeric (Curcuma longa).

4. Studies on spice principles as antioxidants in the inhibition of lipid peroxidation of rat liver microsomes.

5. Incidence of Alzheimer's disease in a rural community in India: the Indo-US study.

6. Inhibitory effect of curcumin, a food spice from turmeric, on platelet-activating factor- and arachidonic acid-mediated platelet aggregation through inhibition of thromboxane formation and Ca2+ signaling.

7. Evidence that increased hippocampal expression of the cytokine interleukin-1 beta is a common trigger for age- and stress-induced impairments in long-term potentiation.

8. Curcumin, a major constituent of turmeric, corrects cystic fibrosis defects.

9. Evaluation of anti-inflammatory property of curcumin (diferuloyl methane) in patients with postoperative inflammation.

10. Preliminary study on antirheumatic activity of curcumin (diferuloyl methane).

1. Induction of oxidative stress and inhibition of superoxide dismutase expression in rat cerebral cortex and cerebellum by PTU-induced hypothyroidism and its reversal by curcumin.

Review 2. Retrospect and prospect of active principles from Chinese herbs in the treatment of dementia.

Review 3. The role of inflammatory processes in Alzheimer's disease.

4. Curcumin and its derivatives: their application in neuropharmacology and neuroscience in the 21st century.

Review 5. Curcumin, the golden nutraceutical: multitargeting for multiple chronic diseases.

Review 6. Amyloid beta-protein assembly as a therapeutic target of Alzheimer's disease.

7. Development of a neuroprotective potential algorithm for medicinal plants.

8. Curcumin for the Treatment of Prostate Diseases: A Systematic Review of Controlled Clinical Trials.

9. The Use of Curcumin for the Treatment of Renal Disorders: A Systematic Review of Randomized Controlled Trials.

Review 10. Curcumin: an orally bioavailable blocker of TNF and other pro-inflammatory biomarkers.