Literature DB >> 15974628

Hectochlorin and morpholine derivatives from the Thai sea hare, Bursatella leachii.

Suchada Suntornchashwej1, Narongsak Chaichit, Minoru Isobe, Khanit Suwanborirux.   

Abstract

Investigation of the EtOAc extract from the Thai sea hare, Bursatella leachii, resulted in the isolation of a potent stimulator of actin assembly, hectochlorin (1), and its new derivative, deacetylhectochlorin (2). Compound 2 exhibited more potent cytotoxicity than 1 against different human carcinoma cell lines. In addition, a new morpholine-2,5-dione analogue, syn-3-isopropyl-6-(4-methoxybenzyl)-4-methylmorpholine-2,5-dione (3), was co-isolated.

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Year:  2005        PMID： 15974628     DOI： 10.1021/np0500124

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  14 in total

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