Literature DB >> 15974627

Terpenoid tetrahydroisoquinoline alkaloids emetine, klugine, and isocephaeline inhibit the activation of hypoxia-inducible factor-1 in breast tumor cells.

Yu-Dong Zhou1, Yong-Pil Kim, Kaleem Asjad Mohammed, Deborah K Jones, Ilias Muhammad, D Chuck Dunbar, Dale G Nagle.   

Abstract

Klugine (1), isocephaeline (2), and emetine (4) inhibited hypoxia-inducible factor-1 (HIF-1) activation by hypoxia in T47D breast tumor cells (IC(50) values 0.2, 1.1, and 0.11 muM, respectively). Compounds 1, 2, and 4 inhibited both hypoxia- and iron chelator-induced HIF-1 activation by blocking HIF-1alpha protein accumulation.

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Year:  2005        PMID： 15974627      PMCID： PMC2907142          DOI： 10.1021/np050029m

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  30 in total

Review 1.  Hypoxia--a key regulatory factor in tumour growth.

Authors:  Adrian L Harris
Journal:  Nat Rev Cancer       Date:  2002-01       Impact factor: 60.716

2.  Suppression of tumor growth through disruption of hypoxia-inducible transcription.

Authors:  A L Kung; S Wang; J M Klco; W G Kaelin; D M Livingston
Journal:  Nat Med       Date:  2000-12       Impact factor: 53.440

3.  Levels of hypoxia-inducible factor-1alpha independently predict prognosis in patients with lymph node negative breast carcinoma.

Authors:  Reinhard Bos; Petra van der Groep; Astrid E Greijer; Avi Shvarts; Sybren Meijer; Herbert M Pinedo; Gregg L Semenza; Paul J van Diest; Elsken van der Wall
Journal:  Cancer       Date:  2003-03-15       Impact factor: 6.860

4.  Levels of hypoxia-inducible factor-1 alpha during breast carcinogenesis.

Authors:  R Bos; H Zhong; C F Hanrahan; E C Mommers; G L Semenza; H M Pinedo; M D Abeloff; J W Simons; P J van Diest; E van der Wall
Journal:  J Natl Cancer Inst       Date:  2001-02-21       Impact factor: 13.506

5.  Carcinogenic metals induce hypoxia-inducible factor-stimulated transcription by reactive oxygen species-independent mechanism.

Authors:  K Salnikow; W Su; M V Blagosklonny; M Costa
Journal:  Cancer Res       Date:  2000-07-01       Impact factor: 12.701

6.  Hypoxia-inducible factor-1alpha is a positive factor in solid tumor growth.

Authors:  H E Ryan; M Poloni; W McNulty; D Elson; M Gassmann; J M Arbeit; R S Johnson
Journal:  Cancer Res       Date:  2000-08-01       Impact factor: 12.701

7.  Molecular determinants of apoptosis induced by the cytotoxic ribonuclease onconase: evidence for cytotoxic mechanisms different from inhibition of protein synthesis.

Authors:  M S Iordanov; O P Ryabinina; J Wong; T H Dinh; D L Newton; S M Rybak; B E Magun
Journal:  Cancer Res       Date:  2000-04-01       Impact factor: 12.701

8.  Hypoxia-inducible factor-1 activation by (-)-epicatechin gallate: potential adverse effects of cancer chemoprevention with high-dose green tea extracts.

Authors:  Yu-Dong Zhou; Yong-Pil Kim; Xing-Cong Li; Scott R Baerson; Ameeta K Agarwal; Tyler W Hodges; Daneel Ferreira; Dale G Nagle
Journal:  J Nat Prod       Date:  2004-12       Impact factor: 4.050

Review 9.  Mechanisms of cell death in hypoxia/reoxygenation injury.

Authors:  P Saikumar; Z Dong; J M Weinberg; M A Venkatachalam
Journal:  Oncogene       Date:  1998-12-24       Impact factor: 9.867

10.  Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases.

Authors:  H Zhong; A M De Marzo; E Laughner; M Lim; D A Hilton; D Zagzag; P Buechler; W B Isaacs; G L Semenza; J W Simons
Journal:  Cancer Res       Date:  1999-11-15       Impact factor: 12.701
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  28 in total

1.  Hypoxia-selective antitumor agents: norsesterterpene peroxides from the marine sponge Diacarnus levii preferentially suppress the growth of tumor cells under hypoxic conditions.

Authors:  Jingqiu Dai; Yang Liu; Yu-Dong Zhou; Dale G Nagle
Journal:  J Nat Prod       Date:  2007-01       Impact factor: 4.050

2.  Marine Natural Products as Inhibitors of Hypoxic Signaling in Tumors.

Authors:  Dale G Nagle; Yu-Dong Zhou
Journal:  Phytochem Rev       Date:  2009-06       Impact factor: 5.374

3.  Catalytic mechanism of aromatic prenylation by NphB.

Authors:  Yue Yang; Yipu Miao; Bing Wang; Guanglei Cui; Kenneth M Merz
Journal:  Biochemistry       Date:  2012-03-12       Impact factor: 3.162

4.  Sodwanone and yardenone triterpenes from a South African species of the marine sponge Axinella inhibit hypoxia-inducible factor-1 (HIF-1) activation in both breast and prostate tumor cells.

Authors:  Jingqiu Dai; James A Fishback; Yu-Dong Zhou; Dale G Nagle
Journal:  J Nat Prod       Date:  2006-12       Impact factor: 4.050

5.  Emetine promotes von Hippel-Lindau-independent degradation of hypoxia-inducible factor-2α in clear cell renal carcinoma.

Authors:  Hye-Sik Kong; Sunmin Lee; Kristin Beebe; Bradley Scroggins; Gopal Gupta; Min-Jung Lee; Yun-Jin Jung; Jane Trepel; Leonard Neckers
Journal:  Mol Pharmacol       Date:  2010-09-02       Impact factor: 4.436

6.  Molecular-targeted antitumor agents. 19. Furospongolide from a marine Lendenfeldia sp. sponge inhibits hypoxia-inducible factor-1 activation in breast tumor cells.

Authors:  Yang Liu; Rui Liu; Shui-Chun Mao; J Brian Morgan; Mika B Jekabsons; Yu-Dong Zhou; Dale G Nagle
Journal:  J Nat Prod       Date:  2008-11-06       Impact factor: 4.050

7.  Cripto-1 is required for hypoxia to induce cardiac differentiation of mouse embryonic stem cells.

Authors:  Caterina Bianco; Catherine Cotten; Enza Lonardo; Luigi Strizzi; Christina Baraty; Mario Mancino; Monica Gonzales; Kazuhide Watanabe; Tadahiro Nagaoka; Colin Berry; Andrew E Arai; Gabriella Minchiotti; David S Salomon
Journal:  Am J Pathol       Date:  2009-10-15       Impact factor: 4.307

8.  Cytotoxic metabolites from an Indonesian sponge Lendenfeldia sp.

Authors:  Jingqiu Dai; Yang Liu; Yu-Dong Zhou; Dale G Nagle
Journal:  J Nat Prod       Date:  2007-10-25       Impact factor: 4.050

9.  Molecular-targeted antitumor agents. 15. Neolamellarins from the marine sponge Dendrilla nigra inhibit hypoxia-inducible factor-1 activation and secreted vascular endothelial growth factor production in breast tumor cells.

Authors:  Rui Liu; Yang Liu; Yu-Dong Zhou; Dale G Nagle
Journal:  J Nat Prod       Date:  2007-10-25       Impact factor: 4.050

10.  Methylalpinumisoflavone inhibits hypoxia-inducible factor-1 (HIF-1) activation by simultaneously targeting multiple pathways.

Authors:  Yang Liu; Coothan K Veena; J Brian Morgan; Kaleem A Mohammed; Mika B Jekabsons; Dale G Nagle; Yu-Dong Zhou
Journal:  J Biol Chem       Date:  2008-12-17       Impact factor: 5.157
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