Literature DB >> 15974626

A cytotoxic xanthone dimer from the entomopathogenic fungus Aschersonia sp. BCC 8401.

Masahiko Isaka1, Somporn Palasarn, Kanokarn Kocharin, Janya Saenboonrueng.   

Abstract

Ascherxanthone A (1), a novel symmetrical tetrahydroxanthone dimer, was isolated from the entomopathogenic fungus Aschersonia sp. BCC 8401. The structure of 1 was elucidated by spectroscopic analysis, especially 2D-NMR. Compound 1 exhibited activity against Plasmodium falciparum K1 with an IC(50) value of 0.20 microg/mL, but it also showed cytotoxic activities against Vero cells and three tumor cell lines.

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Year:  2005        PMID： 15974626     DOI： 10.1021/np058028h

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  6 in total

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2.  Apralactone A and a New Stereochemical Class of Curvularins from the Marine-Derived Fungus Curvularia sp.

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3.  Antiprotozoal and Antibacterial Activity of Ravenelin, a Xanthone Isolated from the Endophytic Fungus Exserohilum rostratum.

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Journal:  Molecules       Date:  2021-06-02       Impact factor: 4.411

4.  Structure revision of cryptosporioptides and determination of the genetic basis for dimeric xanthone biosynthesis in fungi.

Authors:  Claudio Greco; Kate de Mattos-Shipley; Andrew M Bailey; Nicholas P Mulholland; Jason L Vincent; Christine L Willis; Russell J Cox; Thomas J Simpson
Journal:  Chem Sci       Date:  2019-01-21       Impact factor: 9.825

5.  Unusual dimeric tetrahydroxanthone derivatives from Aspergillus lentulus and the determination of their axial chiralities.

Authors:  Tian-Xiao Li; Ming-Hua Yang; Ying Wang; Xiao-Bing Wang; Jun Luo; Jian-Guang Luo; Ling-Yi Kong
Journal:  Sci Rep       Date:  2016-12-12       Impact factor: 4.379

6.  Cytotoxic Tetrahydroxanthone Dimers from the Mangrove-Associated Fungus Aspergillus versicolor HDN1009.

Authors:  Guihong Yu; Guangwei Wu; Zichao Sun; Xiaomin Zhang; Qian Che; Qianqun Gu; Tianjiao Zhu; Dehai Li; Guojian Zhang
Journal:  Mar Drugs       Date:  2018-09-14       Impact factor: 5.118
  6 in total

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