| Literature DB >> 15974576 |
Larisa Oresmaa1, Hanna Kotikoski, Matti Haukka, Johanna Salminen, Olli Oksala, Esko Pohjala, Eeva Moilanen, Heikki Vapaatalo, Pirjo Vainiotalo, Paula Aulaskari.
Abstract
Novel 1-R-imidazole-2-nitrolic acids and 1-R-imidazole-5-nitrolic acids (R: H, Me, Bn) were synthesized from oximes by treatment with a mixture of fuming nitric acid and acetic acid. The effects of these potential nitric oxide-donating compounds were tested on ocular variables such as intraocular pressure and formation of cyclic guanosine-3,5'-monophosphate in the incubation of porcine iris-ciliary body.Entities:
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Year: 2005 PMID： 15974576 DOI： 10.1021/jm048949+
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446