Literature DB >> 15974575

Peptoid-peptide hybrids as potent novel melanocortin receptor ligands.

John A W Kruijtzer1, Wouter A J Nijenhuis, Nienke Wanders, Willem Hendrik Gispen, Rob M J Liskamp, Roger A H Adan.   

Abstract

All possible peptoid-peptide hybrids of an MC4 receptor agonist were synthesized and investigated on cells expressing different melanocortin (MC) receptor subtypes and for rat grooming behavior. In general, receptor selectivity remained while affinity and potency were decreased. The length of the functional group of Trp was more important for MC3 and MC5 than for MC4 receptor binding. In general, the potency of the peptoid-peptide hybrids to increase rat excessive grooming behavior correlated well with MC4 receptor pharmacology.

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Year:  2005        PMID： 15974575     DOI： 10.1021/jm0490033

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


  8 in total

1.  Fragmentation Patterns and Mechanisms of Singly and Doubly Protonated Peptoids Studied by Collision Induced Dissociation.

Authors:  Jianhua Ren; Yuan Tian; Ekram Hossain; Michael D Connolly
Journal:  J Am Soc Mass Spectrom       Date:  2016-02-01       Impact factor: 3.109

2.  Hydrazone- and hydrazide-containing N-substituted glycines as peptoid surrogates for expedited library synthesis: application to the preparation of Tsg101-directed HIV-1 budding antagonists.

Authors:  Fa Liu; Andrew G Stephen; Catherine S Adamson; Karine Gousset; M Javad Aman; Eric O Freed; Robert J Fisher; Terrence R Burke
Journal:  Org Lett       Date:  2006-10-26       Impact factor: 6.005

3.  Biomimetic nanostructures: creating a high-affinity zinc-binding site in a folded nonbiological polymer.

Authors:  Byoung-Chul Lee; Tammy K Chu; Ken A Dill; Ronald N Zuckermann
Journal:  J Am Chem Soc       Date:  2008-07-09       Impact factor: 15.419

4.  Electron capture dissociation studies of the fragmentation patterns of doubly protonated and mixed protonated-sodiated peptoids.

Authors:  Bogdan Bogdanov; Xiaoning Zhao; David B Robinson; Jianhua Ren
Journal:  J Am Soc Mass Spectrom       Date:  2014-05-21       Impact factor: 3.109

5.  Design, synthesis, and biological evaluation of new cyclic melanotropin peptide analogues selective for the human melanocortin-4 receptor.

Authors:  Jinfa Ying; Xuyuan Gu; Minying Cai; Matthew Dedek; Josef Vagner; Dev B Trivedi; Victor J Hruby
Journal:  J Med Chem       Date:  2006-11-16       Impact factor: 7.446

6.  Synthesis and Mass Spectrometry Analysis of Oligo-peptoids.

Authors:  Jianhua Ren; Yadwinder S Mann; Yuntao Zhang; Michael D Browne
Journal:  J Vis Exp       Date:  2018-02-21       Impact factor: 1.355

Review 7.  The identification of high-affinity G protein-coupled receptor ligands from large combinatorial libraries using multicolor quantum dot-labeled cell-based screening.

Authors:  Junjie Fu; Timothy Lee; Xin Qi
Journal:  Future Med Chem       Date:  2014-05       Impact factor: 3.808

8.  Peptoid-Peptide hybrid ligands targeting the polo box domain of polo-like kinase 1.

Authors:  Fa Liu; Jung-Eun Park; Wen-Jian Qian; Dan Lim; Andrej Scharow; Thorsten Berg; Michael B Yaffe; Kyung S Lee; Terrence R Burke
Journal:  Chembiochem       Date:  2012-05-08       Impact factor: 3.164
  8 in total

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