| Literature DB >> 15974571 |
Ronghui Lin1, Peter J Connolly, Shenlin Huang, Steven K Wetter, Yanhua Lu, William V Murray, Stuart L Emanuel, Robert H Gruninger, Angel R Fuentes-Pesquera, Catherine A Rugg, Steven A Middleton, Linda K Jolliffe.
Abstract
A series of 1-acyl-1H-[1,2,4]triazole-3,5-diamine analogues were synthesized as cyclin-dependent kinase (CDK) inhibitors. These compounds showed potent and selective CDK1 and CDK2 inhibitory activities and inhibited in vitro cellular proliferation in various human tumor cells. Representative compound 3b demonstrated in vivo efficacy in a human melanoma A375 xenograft model in nude mice.Entities:
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Year: 2005 PMID： 15974571 DOI： 10.1021/jm050267e
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446