Literature DB >> 15974085

Development of a headspace gas chromatography method to determine residual aliphatic amines in oligonucleotides.

Grant Von Wald1, Dave Albers, Larry Nicholson, Marsha Langhorst, Bruce Bell.   

Abstract

A headspace gas chromatographic method has been developed for analysis of aliphatic amines in oligonucleotides. The linearity was improved by including ammonia in the sample vials. Also, carryover of longer chain primary amines, hexylamine and octylamine, was substantially reduced by cleaning the injection syringe with ammonia and water vapor between sample injections.

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Year:  2005        PMID: 15974085     DOI: 10.1016/j.chroma.2005.04.052

Source DB:  PubMed          Journal:  J Chromatogr A        ISSN: 0021-9673            Impact factor:   4.759


  1 in total

1.  Development and validation of a gas chromatography method for the trace level determination of allylamine in sevelamer hydrochloride and sevelamer carbonate drug substances.

Authors:  Raju V S N Kadiyala; Pavan Kumar S R Kothapalli; Madhava Reddy Peddolla; Pradeep Rajput; Hemant Kumar Sharma; Shankar Reddy Budeti; Himabindu Gandham; Annapurna Nowduri
Journal:  Sci Pharm       Date:  2013-11-14
  1 in total

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