| Literature DB >> 15972548 |
Sergio Lizano1, Kenneth H Johnston.
Abstract
The beta domain of streptokinase is required for plasminogen activation and contains a region of sequence diversity associated with infection and disease in group A streptococci. We report that mutagenesis of this polymorphic region does not alter plasminogen activation, which suggests an alternative function for this molecular motif in streptococcal disease.Entities:
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Year: 2005 PMID: 15972548 PMCID: PMC1168554 DOI: 10.1128/IAI.73.7.4451-4453.2005
Source DB: PubMed Journal: Infect Immun ISSN: 0019-9567 Impact factor: 3.441