Literature DB >> 15972547

Genome scale identification of Treponema pallidum antigens.

Matthew McKevitt1, Mary Beth Brinkman, Melanie McLoughlin, Carla Perez, Jerrilyn K Howell, George M Weinstock, Steven J Norris, Timothy Palzkill.   

Abstract

Antibody responses for 882 of the 1,039 proteins in the proteome of Treponema pallidum were examined. Sera collected from infected rabbits were used to systematically identify 106 antigenic proteins, including 22 previously identified antigens and 84 novel antigens. Additionally, sera collected from rabbits throughout the course of infection demonstrated a progression in the breadth and intensity of humoral immunoreactivity against a representative panel of T. pallidum antigens.

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Year:  2005        PMID： 15972547      PMCID： PMC1168556          DOI： 10.1128/IAI.73.7.4445-4450.2005

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  33 in total

1.  Identification of homologs for thioredoxin, peptidyl prolyl cis-trans isomerase, and glycerophosphodiester phosphodiesterase in outer membrane fractions from Treponema pallidum, the syphilis spirochete.

Authors:  D V Shevchenko; D R Akins; E J Robinson; M Li; O V Shevchenko; J D Radolf
Journal:  Infect Immun       Date:  1997-10       Impact factor: 3.441

2.  Identification of Treponema pallidum subspecies pallidum genes encoding signal peptides and membrane-spanning sequences using a novel alkaline phosphatase expression vector.

Authors:  D R Blanco; M Giladi; C I Champion; D A Haake; G K Chikami; J N Miller; M A Lovett
Journal:  Mol Microbiol       Date:  1991-10       Impact factor: 3.501

3.  Identification and transcriptional analysis of a Treponema pallidum operon encoding a putative ABC transport system, an iron-activated repressor protein homolog, and a glycolytic pathway enzyme homolog.

Authors:  J M Hardham; L V Stamm; S F Porcella; J G Frye; N Y Barnes; J K Howell; S L Mueller; J D Radolf; G M Weinstock; S J Norris
Journal:  Gene       Date:  1997-09-15       Impact factor: 3.688

4.  Molecular characterization and cellular localization of TpLRR, a processed leucine-rich repeat protein of Treponema pallidum, the syphilis spirochete.

Authors:  D V Shevchenko; D R Akins; E Robinson; M Li; T G Popova; D L Cox; J D Radolf
Journal:  J Bacteriol       Date:  1997-05       Impact factor: 3.490

5.  Sequence analysis and recombinant expression of a 28-kilodalton Treponema pallidum subsp. pallidum rare outer membrane protein (Tromp2).

Authors:  C I Champion; D R Blanco; M M Exner; H Erdjument-Bromage; R E Hancock; P Tempst; J N Miller; M A Lovett
Journal:  J Bacteriol       Date:  1997-02       Impact factor: 3.490

6.  Recombinant Treponema pallidum rare outer membrane protein 1 (Tromp1) expressed in Escherichia coli has porin activity and surface antigenic exposure.

Authors:  D R Blanco; C I Champion; M M Exner; E S Shang; J T Skare; R E Hancock; J N Miller; M A Lovett
Journal:  J Bacteriol       Date:  1996-12       Impact factor: 3.490

7.  Characterization of the 35-kilodalton Treponema pallidum subsp. pallidum recombinant lipoprotein TmpC and antibody response to lipidated and nonlipidated T. pallidum antigens.

Authors:  L M Schouls; H G van der Heide; J D van Embden
Journal:  Infect Immun       Date:  1991-10       Impact factor: 3.441

8.  Characterization of lipid-modified immunogenic proteins of Treponema pallidum expressed in Escherichia coli.

Authors:  L M Schouls; R Mout; J Dekker; J D van Embden
Journal:  Microb Pathog       Date:  1989-09       Impact factor: 3.738

Review 9.  Polypeptides of Treponema pallidum: progress toward understanding their structural, functional, and immunologic roles. Treponema Pallidum Polypeptide Research Group.

Authors:  S J Norris
Journal:  Microbiol Rev       Date:  1993-09

10.  Treponema pallidum in gel microdroplets: a novel strategy for investigation of treponemal molecular architecture.

Authors:  D L Cox; D R Akins; S F Porcella; M V Norgard; J D Radolf
Journal:  Mol Microbiol       Date:  1995-03       Impact factor: 3.501
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  29 in total

Review 1.  Syphilis: using modern approaches to understand an old disease.

Authors:  Emily L Ho; Sheila A Lukehart
Journal:  J Clin Invest       Date:  2011-12-01       Impact factor: 14.808

2.  TP0326, a Treponema pallidum β-barrel assembly machinery A (BamA) orthologue and rare outer membrane protein.

Authors:  Daniel C Desrosiers; Arvind Anand; Amit Luthra; Star M Dunham-Ems; Morgan LeDoyt; Michael A D Cummings; Azad Eshghi; Caroline E Cameron; Adriana R Cruz; Juan C Salazar; Melissa J Caimano; Justin D Radolf
Journal:  Mol Microbiol       Date:  2011-04-27       Impact factor: 3.501

3.  Characterization and serologic analysis of the Treponema pallidum proteome.

Authors:  Melanie A McGill; Diane G Edmondson; James A Carroll; Richard G Cook; Ralph S Orkiszewski; Steven J Norris
Journal:  Infect Immun       Date:  2010-04-12       Impact factor: 3.441

Review 4.  Genetic diversity in Treponema pallidum: implications for pathogenesis, evolution and molecular diagnostics of syphilis and yaws.

Authors:  David Smajs; Steven J Norris; George M Weinstock
Journal:  Infect Genet Evol       Date:  2011-12-15       Impact factor: 3.342

5.  Immunoproteomic analysis of human serological antibody responses to vaccination with whole-cell pertussis vaccine (WCV).

Authors:  Yong-Zhang Zhu; Cheng-Song Cai; Wei Zhang; Hong-Xiong Guo; Jin-Ping Zhang; Ya-Yong Ji; Guang-Yuan Ma; Jia-Lin Wu; Qing-Tian Li; Cheng-Ping Lu; Xiao-Kui Guo
Journal:  PLoS One       Date:  2010-11-09       Impact factor: 3.240

6.  Genome differences between Treponema pallidum subsp. pallidum strain Nichols and T. paraluiscuniculi strain Cuniculi A.

Authors:  Michal Strouhal; David Smajs; Petra Matejková; Erica Sodergren; Anita G Amin; Jerrilyn K Howell; Steven J Norris; George M Weinstock
Journal:  Infect Immun       Date:  2007-09-24       Impact factor: 3.441

7.  Assessment of cell-surface exposure and vaccinogenic potentials of Treponema pallidum candidate outer membrane proteins.

Authors:  Farol L Tomson; Patrick G Conley; Michael V Norgard; Kayla E Hagman
Journal:  Microbes Infect       Date:  2007-06-03       Impact factor: 2.700

8.  Activation and proteolytic activity of the Treponema pallidum metalloprotease, pallilysin.

Authors:  Simon Houston; Rebecca Hof; Lisa Honeyman; Julia Hassler; Caroline E Cameron
Journal:  PLoS Pathog       Date:  2012-07-26       Impact factor: 6.823

9.  A genome-wide proteome array reveals a limited set of immunogens in natural infections of humans and white-footed mice with Borrelia burgdorferi.

Authors:  Alan G Barbour; Algimantas Jasinskas; Matthew A Kayala; D Huw Davies; Allen C Steere; Pierre Baldi; Philip L Felgner
Journal:  Infect Immun       Date:  2008-05-12       Impact factor: 3.441

10.  A novel Treponema pallidum antigen, TP0136, is an outer membrane protein that binds human fibronectin.

Authors:  Mary Beth Brinkman; Melanie A McGill; Jonas Pettersson; Arthur Rogers; Petra Matejková; David Smajs; George M Weinstock; Steven J Norris; Timothy Palzkill
Journal:  Infect Immun       Date:  2008-03-10       Impact factor: 3.441
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