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Literature DB >> 15972536

Role of motility and flagellin glycosylation in the pathogenesis of Pseudomonas aeruginosa burn wound infections.

Shiwani K Arora¹, Alice N Neely, Barbara Blair, Stephen Lory, Reuben Ramphal.

Abstract

In this study, we tested the contribution of flagellar motility, flagellin structure, and its glycosylation in Pseudomonas aeruginosa using genetically defined flagellar mutants. All mutants and their parent strains were tested in a burned-mouse model of infection. Motility and glycosylation of the flagellum appear to be important determinants of flagellar-mediated virulence in this model. This is the first report where genetically defined flagellar variants of P. aeruginosa were tested in the burned-mouse model of infection.

Entities: Disease Species

Mesh：

Substances：
Flagellin

Year: 2005 PMID： 15972536 PMCID： PMC1168557 DOI： 10.1128/IAI.73.7.4395-4398.2005

Source DB: PubMed Journal: Infect Immun ISSN： 0019-9567 Impact factor: 3.441

32 in total

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Journal: Burns Date: 1999-11 Impact factor: 2.744

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Journal: J Bacteriol Date: 1998-06 Impact factor: 3.490

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Journal: Infect Immun Date: 1998-03 Impact factor: 3.441

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Authors: Amrisha Verma; Michael Schirm; Shiwani K Arora; P Thibault; Susan M Logan; Reuben Ramphal
Journal: J Bacteriol Date: 2006-06 Impact factor: 3.490

8. Role of flagella in pathogenesis of Pseudomonas aeruginosa pulmonary infection.

Authors: M Feldman; R Bryan; S Rajan; L Scheffler; S Brunnert; H Tang; A Prince
Journal: Infect Immun Date: 1998-01 Impact factor: 3.441

9. Avirulence of a Pseudomonas aeruginosa algC mutant in a burned-mouse model of infection.

Authors: J B Goldberg; M J Coyne; A N Neely; I A Holder
Journal: Infect Immun Date: 1995-10 Impact factor: 3.441

10. A broad-host-range Flp-FRT recombination system for site-specific excision of chromosomally-located DNA sequences: application for isolation of unmarked Pseudomonas aeruginosa mutants.

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Journal: Gene Date: 1998-05-28 Impact factor: 3.688

57 in total

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Journal: J Bacteriol Date: 2011-04-22 Impact factor: 3.490

2. Influence of Pseudomonas aeruginosa pvdQ gene on altering antibiotic susceptibility under swarming conditions.

Authors: Lili Wang; Chunling Zhang; Fengyun Gong; Hongtao Li; Xuhua Xie; Chao Xia; Jia Chen; Ying Song; Aixia Shen; Jianxin Song
Journal: Curr Microbiol Date: 2011-08-11 Impact factor: 2.188

3. Effects of glycosylation on swimming ability and flagellar polymorphic transformation in Pseudomonas syringae pv. tabaci 6605.

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Journal: J Bacteriol Date: 2007-11-16 Impact factor: 3.490

4. Transcriptional organization of the region encoding the synthesis of the flagellar filament in Pseudomonas fluorescens.

Authors: Miguel Redondo-Nieto; Javier Lloret; Javiera Larenas; Emma Barahona; Ana Navazo; Francisco Martínez-Granero; Silvia Capdevila; Rafael Rivilla; Marta Martín
Journal: J Bacteriol Date: 2008-03-28 Impact factor: 3.490