PURPOSE: To determine the evolution of the ischemic lesion volumes in a population treated with tissue plasminogen activator (t-PA), MRIs were performed before treatment and 24 hours later; final infarct size was evaluated 60 days later. MATERIALS AND METHODS: A total of 42 patients with hemispheric stroke were recruited for a thrombolytic study. Intravenous t-PA was given after MRI within the first seven hours after stroke onset. Volumes were evaluated on day 0 and day 1 with diffusion-weighted imaging (DWI), on day 60 with T2-weighted imaging (T2WI), and recanalization was assessed based on day 1 MR angiography (MRA). RESULTS: Lesion volume increased between day 0 and day 1, and decreased between day 1 and day 60. It was lower in the group of patients with recanalization on day 1 MRA. CONCLUSION: Volume analysis emphasizes the effectiveness of recanalization as a predictive factor for better outcome, based on final infarct size. The decrease in lesion volumes between day 1 and day 60 suggests that other factors leads to overestimation of day 1 abnormal diffusion volume. This could explain the delayed partial reversibility of the DWI abnormality.
PURPOSE: To determine the evolution of the ischemic lesion volumes in a population treated with tissue plasminogen activator (t-PA), MRIs were performed before treatment and 24 hours later; final infarct size was evaluated 60 days later. MATERIALS AND METHODS: A total of 42 patients with hemispheric stroke were recruited for a thrombolytic study. Intravenous t-PA was given after MRI within the first seven hours after stroke onset. Volumes were evaluated on day 0 and day 1 with diffusion-weighted imaging (DWI), on day 60 with T2-weighted imaging (T2WI), and recanalization was assessed based on day 1 MR angiography (MRA). RESULTS: Lesion volume increased between day 0 and day 1, and decreased between day 1 and day 60. It was lower in the group of patients with recanalization on day 1 MRA. CONCLUSION: Volume analysis emphasizes the effectiveness of recanalization as a predictive factor for better outcome, based on final infarct size. The decrease in lesion volumes between day 1 and day 60 suggests that other factors leads to overestimation of day 1 abnormal diffusion volume. This could explain the delayed partial reversibility of the DWI abnormality.
Authors: T-H Cho; N Nighoghossian; F Tahon; C Némoz; M Hermier; F Salkine; L Derex; P Trouillas; J-C Froment; F Turjman Journal: AJNR Am J Neuroradiol Date: 2008-09-03 Impact factor: 3.825
Authors: Martin R Gaudinski; Erica C Henning; Aaron Miracle; Marie Luby; Steven Warach; Lawrence L Latour Journal: Stroke Date: 2008-07-17 Impact factor: 7.914
Authors: José G Merino; Lawrence L Latour; Jason W Todd; Marie Luby; Peter D Schellinger; Dong-Wha Kang; Steven Warach Journal: Stroke Date: 2007-09-27 Impact factor: 7.914