Literature DB >> 15970068

The prescribing of methadone and other opioids to addicts: national survey of GPs in England and Wales.

John Strang1, Janie Sheridan, Claire Hunt, Bethanne Kerr, Clare Gerada, Michael Pringle.   

Abstract

BACKGROUND: GPs occupy a pivotal position in relation to providing services to opiate misusers in the UK, and this is now cited to support initiatives in other countries. AIMS: To investigate GP involvement in the management of opiate misusers; and to examine the nature of this prescribing of methadone and other opioids.
DESIGN: GP data collected via self-completion postal questionnaire from a 10% random sample of the 30 000 GPs across England and Wales. Patient prescription data obtained on opiate misusers treated during the preceding 4 weeks.
SETTING: Primary healthcare practice in England and Wales in mid-2001.
METHOD: A questionnaire was mailed to a random 10% sample of GPs stratified by number of partners in the practice, with three follow-up mailshots. Data on drugs prescribed by these practitioners were also studied, including drug prescribed, form, dose and dispensing arrangements.
RESULTS: The response rate was 66%. Opiate misusers had been seen by 51% of GPs in the preceding 4 weeks (mean of 4.1 such patients), of whom 50% had prescribed opiate-substitution drugs. This provided a study sample of 1482 opiate misusers to whom GPs were prescribing methadone (86.7%), dihydrocodeine (8.5%) or buprenorphine (4.4%). Of 1292 methadone prescriptions, mean daily dose was 36.9 mg - 47.9% being for 30 mg or less. Daily interval dispensing was stipulated by 44.6%, while 42.9% permitted weekly take-away supply.
CONCLUSIONS: In 2001 nearly three times as many GPs were seeing opiate misusers than was the case in 1985. Half were prescribing substitute-opiate drugs such as methadone (to an estimated 30 000 patients). However, there are grounds for concern about the quality of this prescribing. Most doses were too low to constitute optimal methadone maintenance; widespread disregard of the availability of supervised or interval dispensing increases the risks of diversion to the blackmarket and deaths from methadone overdose. Increased quantity of care has been achieved. Increased quality is now required.

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Year:  2005        PMID: 15970068      PMCID: PMC1472740     

Source DB:  PubMed          Journal:  Br J Gen Pract        ISSN: 0960-1643            Impact factor:   5.386


  28 in total

1.  A review of shared care protocols for the treatment of problem drug use in England, Scotland, and Wales.

Authors:  C Gerada; J Tighe
Journal:  Br J Gen Pract       Date:  1999-02       Impact factor: 5.386

2.  Differences between general practitioner- and addiction centre-prescribed buprenorphine substitution therapy in France. Preliminary results.

Authors:  J Vignau; E Brunelle
Journal:  Eur Addict Res       Date:  1998       Impact factor: 3.015

3.  Effect of government recommendations on methadone prescribing in South East England: comparison of 1995 and 1997 surveys.

Authors:  J Strang; J Sheridan
Journal:  BMJ       Date:  1998-11-28

4.  French general practitioners' attitudes toward maintenance drug abuse treatment with buprenorphine.

Authors:  J P Moatti; M Souville; N Escaffre; Y Obadia
Journal:  Addiction       Date:  1998-10       Impact factor: 6.526

5.  Characteristics of fatal methadone overdose in Manchester, 1985-94.

Authors:  A Cairns; I S Roberts; E W Benbow
Journal:  BMJ       Date:  1996-08-03

6.  General practitioner centred scheme for treatment of opiate dependent drug injectors in Glasgow.

Authors:  L Gruer; P Wilson; R Scott; L Elliott; J Macleod; K Harden; E Forrester; S Hinshelwood; H McNulty; P Silk
Journal:  BMJ       Date:  1997-06-14

7.  Surveying general practitioners: does a low response rate matter?

Authors:  L Templeton; A Deehan; C Taylor; C Drummond; J Strang
Journal:  Br J Gen Pract       Date:  1997-02       Impact factor: 5.386

8.  Moderate- vs high-dose methadone in the treatment of opioid dependence: a randomized trial.

Authors:  E C Strain; G E Bigelow; I A Liebson; M L Stitzer
Journal:  JAMA       Date:  1999-03-17       Impact factor: 56.272

9.  Prescribing injectable and oral methadone to opiate addicts: results from the 1995 national postal survey of community pharmacies in England and Wales.

Authors:  J Strang; J Sheridan; N Barber
Journal:  BMJ       Date:  1996-08-03

Review 10.  Role of maintenance treatment in opioid dependence.

Authors:  J Ward; W Hall; R P Mattick
Journal:  Lancet       Date:  1999-01-16       Impact factor: 79.321

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  26 in total

1.  Comparison of methadone and buprenorphine for opiate detoxification (LEEDS trial): a randomised controlled trial.

Authors:  Nat M J Wright; Laura Sheard; Clive E Adams; Bruno J Rushforth; Wendy Harrison; Nicole Bound; Roger Hart; Charlotte N E Tompkins
Journal:  Br J Gen Pract       Date:  2011-12       Impact factor: 5.386

2.  Treating addiction.

Authors:  John Sharvill
Journal:  Br J Gen Pract       Date:  2005-07       Impact factor: 5.386

3.  Prescribing to substance misusers.

Authors:  Stephen Willott
Journal:  Br J Gen Pract       Date:  2005-08       Impact factor: 5.386

4.  Prescribing to substance misusers. Letter response.

Authors:  Stephen Willott
Journal:  Br J Gen Pract       Date:  2006-04       Impact factor: 5.386

Review 5.  Methadone tolerance testing in drug misusers.

Authors:  Adam Bakker; Cindy Fazey
Journal:  BMJ       Date:  2006-11-18

6.  [Medical quality circles for drug replacement therapy].

Authors:  Hans Tönies; Manfred Maier; Andjela Bäwert
Journal:  Wien Med Wochenschr       Date:  2006-08

7.  Emergency naloxone for heroin overdose: over the counter availability needs careful consideration.

Authors:  Andrew Byrne
Journal:  BMJ       Date:  2006-10-07

8.  Drug misusers and incentives: Methadone works if used properly.

Authors:  Andrew Byrne
Journal:  BMJ       Date:  2007-09-08

9.  Psychosocial interventions and opioid detoxification for drug misuse: summary of NICE guidance.

Authors:  Stephen Pilling; John Strang; Clare Gerada
Journal:  BMJ       Date:  2007-07-28

Review 10.  Can antiviral treatment for hepatitis C be safely and effectively delivered in primary care?: a narrative systematic review of the evidence base.

Authors:  Iain F Brew; Christine Butt; Nat Wright
Journal:  Br J Gen Pract       Date:  2013-12       Impact factor: 5.386

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