OBJECTIVE: To investigate the histopathological features of pathologic parathyroid specimens associated with negative preoperative technetium Tc 99m sestamibi scans. DESIGN: Retrospective study. SETTING: Tertiary care center. PATIENTS: One hundred fourteen patients who underwent sestamibi scans before surgical exploration for primary hyperparathyroidism between 1996 and 2001. INTERVENTIONS: Surgical exploration and removal of parathyroid adenomas. MAIN OUTCOME MEASURES: Histopathological characteristics associated with true-positive and false-negative sestamibi scans, including parathyroid specimen weight, size, relative oxyphil and chief cell content, parathyroid hormone staining patterns, cellular architecture, and various immunohistochemical staining patterns. RESULTS: Twenty-three (24%) of 98 patients with parathyroid adenomas had negative sestamibi scan results. Among 20 age- and sex-matched patients with false-negative results vs 20 patients with true-positive results, tumor size (P = .04) and oxyphil cell content (P = .03) were found to be significantly different. CONCLUSION: Parathyroid gland size and oxyphil content are descriptive and predict differences between sestamibi properties of parathyroid adenomas but have no current therapeutic implications for parathyroid surgery.
OBJECTIVE: To investigate the histopathological features of pathologic parathyroid specimens associated with negative preoperative technetium Tc 99msestamibi scans. DESIGN: Retrospective study. SETTING: Tertiary care center. PATIENTS: One hundred fourteen patients who underwent sestamibi scans before surgical exploration for primary hyperparathyroidism between 1996 and 2001. INTERVENTIONS: Surgical exploration and removal of parathyroid adenomas. MAIN OUTCOME MEASURES: Histopathological characteristics associated with true-positive and false-negative sestamibi scans, including parathyroid specimen weight, size, relative oxyphil and chief cell content, parathyroid hormone staining patterns, cellular architecture, and various immunohistochemical staining patterns. RESULTS: Twenty-three (24%) of 98 patients with parathyroid adenomas had negative sestamibi scan results. Among 20 age- and sex-matched patients with false-negative results vs 20 patients with true-positive results, tumor size (P = .04) and oxyphil cell content (P = .03) were found to be significantly different. CONCLUSION: Parathyroid gland size and oxyphil content are descriptive and predict differences between sestamibi properties of parathyroid adenomas but have no current therapeutic implications for parathyroid surgery.
Authors: W Jalloul; R Tibu; T M Ionescu; C R Stolniceanu; I Grierosu; A Tarca; L Ionescu; M C Ungureanu; D Ciobanu; V Ghizdovat; C Stefanescu Journal: Acta Endocrinol (Buchar) Date: 2021 Jul-Sep Impact factor: 0.877
Authors: Subramanian Kannan; Mira Milas; Donald Neumann; Rikesh T Parikh; Alan Siperstein; Angelo Licata Journal: Clin Cases Miner Bone Metab Date: 2014-01
Authors: Linwah Yip; Daniel A Pryma; John H Yim; Mohamed A Virji; Sally E Carty; Jennifer B Ogilvie Journal: World J Surg Date: 2008-05 Impact factor: 3.352