| Literature DB >> 15967759 |
Charmagne G Beckett1, Herman Kosasih, Indra Faisal, Ratna Tan, Susana Widjaja, Erlin Listiyaningsih, Chairin Ma'roef, Suharyono Wuryadi, Michael J Bangs, Tatang K Samsi, Djoko Yuwono, Curtis G Hayes, Kevin R Porter.
Abstract
A two-year study using a cluster investigation method was conducted in West Jakarta, Indonesia to demonstrate the detection of dengue cases prior to onset of clinical illness. The clusters consisted of family members and neighbors of 53 hospitalized dengue index cases. Among 785 adult and child volunteers enrolled, 17 (2.2%) post-enrollment dengue (PED) infections were identified. Eight PED cases were asymptomatic and nine were symptomatic. Symptomatic cases included eight with dengue fever and one with dengue hemorrhagic fever (DHF) (grade II). Among the eight asymptomatic PED cases, viremia was detected in two. Eleven volunteers had acute dengue infections at the time of enrollment. Four of the 11 developed DHF, resulting in a total of five DHF cases detected during the investigation. This study design can serve as a benchmark for future investigations that seek to define early immunologic events following dengue infections that contribute to the development of DHF.Entities:
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Year: 2005 PMID： 15967759
Source DB: PubMed Journal: Am J Trop Med Hyg ISSN： 0002-9637 Impact factor: 2.345