Literature DB >> 15966133

Anti-Mi-2 antibodies.

Anna Ghirardello1, Sandra Zampieri, Luca Iaccarino, Elena Tarricone, Raffaele Bendo, Pier Franca Gambari, Andrea Doria.   

Abstract

Autoantibodies targeting the Mi-2 nuclear antigen represent one of the serologic hallmarks of idiopathic inflammatory myopathies, with a diagnostic sensitivity and specificity of approximately 4-18% and 98-100%, respectively. Mi-2 antigen is a component of the nuclesome remodeling-deacetylase (NuRD) complex involved in transcription regulation.Anti-Mi-2 antibodies are strongly associated with dermatomyositis (frequency up to 31%) and have a very high positive predictive value for such disease subset. A strong correlation with HLA-DR7 has been demonstrated. At the moment, optimal serologic testing is achieved by ELISA screening on recombinant Mi-2 antigen and confirmation of positive results on immunoblot.

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Year:  2005        PMID： 15966133     DOI： 10.1080/08916930400022681

Source DB:  PubMed          Journal:  Autoimmunity        ISSN： 0891-6934            Impact factor:   2.815


  35 in total

1.  The olfactory function is impaired in patients with idiopathic inflammatory myopathies.

Authors:  L Iaccarino; N Shoenfeld; M Rampudda; M Zen; M Gatto; A Ghirardello; N Bassi; L Punzi; Y Shoenfeld; A Doria
Journal:  Immunol Res       Date:  2014-12       Impact factor: 2.829

2.  Clinical characteristics of patients with myositis and autoantibodies to different fragments of the Mi-2 beta antigen.

Authors:  G J D Hengstman; W T M Vree Egberts; H P Seelig; I E Lundberg; H M Moutsopoulos; A Doria; M Mosca; J Vencovsky; W J van Venrooij; B G M van Engelen
Journal:  Ann Rheum Dis       Date:  2006-02       Impact factor: 19.103

3.  UV radiation regulates Mi-2 through protein translation and stability.

Authors:  Craig J Burd; H Karimi Kinyamu; Frederick W Miller; Trevor K Archer
Journal:  J Biol Chem       Date:  2008-10-15       Impact factor: 5.157

Review 4.  Juvenile dermatomyositis: advances in clinical presentation, myositis-specific antibodies and treatment.

Authors:  Jian-Qiang Wu; Mei-Ping Lu; Ann M Reed
Journal:  World J Pediatr       Date:  2019-09-26       Impact factor: 2.764

Review 5.  Dermatomyositis.

Authors:  M S Krathen; D Fiorentino; V P Werth
Journal:  Curr Dir Autoimmun       Date:  2008

Review 6.  Myositis-related interstitial lung disease and antisynthetase syndrome.

Authors:  Joshua Solomon; Jeffrey J Swigris; Kevin K Brown
Journal:  J Bras Pneumol       Date:  2011 Jan-Feb       Impact factor: 2.624

Review 7.  Diagnostic Imaging of Inflammatory Myopathies: New Concepts and a Radiological Approach.

Authors:  Júlio Brandão Guimarães; Marcelo A Nico; Alípio G Omond; Laís Uyeda Aivazoglou; Rafael Baches Jorge; Edmar Zanoteli; Artur R C Fernandes
Journal:  Curr Rheumatol Rep       Date:  2019-02-14       Impact factor: 4.592

8.  Anti-melanoma differentiation-associated protein 5-associated dermatomyositis: expanding the clinical spectrum.

Authors:  John C Hall; Livia Casciola-Rosen; Lesly-Ann Samedy; Jessie Werner; Kristie Owoyemi; Sonye K Danoff; Lisa Christopher-Stine
Journal:  Arthritis Care Res (Hoboken)       Date:  2013-08       Impact factor: 4.794

Review 9.  Calcinosis and malignancy are rare in Chinese adult patients with myositis and nuclear matrix protein 2 antibodies identified by an unlabeled immunoprecipitation assay.

Authors:  Li Wang; Li Huang; Yang Yang; Huan Chen; Yanjuan Liu; Ke Liu; Meidong Liu; Yizhi Xiao; Hui Luo; Xiaoxia Zuo; Yisha Li; Xianzhong Xiao; Huali Zhang
Journal:  Clin Rheumatol       Date:  2018-07-23       Impact factor: 2.980

10.  Expression of the dermatomyositis autoantigen Mi-2 in regenerating muscle.

Authors:  Andrew L Mammen; Livia A Casciola-Rosen; John C Hall; Lisa Christopher-Stine; Andrea M Corse; Antony Rosen
Journal:  Arthritis Rheum       Date:  2009-12
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