| Literature DB >> 15964664 |
Jacquelien J G Hillebrand1, Martien J H Kas, Roger A H Adan.
Abstract
Activity-based anorexia (ABA) is considered an animal model of anorexia nervosa (AN). In ABA, scheduled feeding in combination with voluntary access to running wheels, results in hyperactivity, hypophagia, body weight loss and activation of the HPA axis. Since stimulation of the melanocortin (MC) system has similar effects, this system is a candidate system involved in ABA. Here it is shown that chronic alpha-MSH treatment enhances ABA by increasing running wheel activity (RWA), decreasing food intake and increasing HPA axis activation.Entities:
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Year: 2005 PMID： 15964664 DOI： 10.1016/j.peptides.2004.11.027
Source DB: PubMed Journal: Peptides ISSN： 0196-9781 Impact factor: 3.750