| Literature DB >> 15964479 |
M Teresa Valenzuela1, R Jake Jacobs, Oscar Arteaga, Maria S Navarrete, Allen S Meyerhoff, Bruce L Innis.
Abstract
Hepatitis A is an important public health problem in Chile. Childhood vaccination has reduced hepatitis A rates in several countries, prompting this evaluation of its cost-effectiveness in Chile. Using a Markov model, we project mass vaccination would reduce hepatitis A cases among birth cohort members and their personal contacts >80%. Vaccination costs of US dollars 5.3-6.4 million would be offset by US dollars 9.2-9.4 million reductions in disease costs. Further, approximately 70 fatal infections would be averted and >4600 quality-adjusted life years would be saved. This analysis supports the cost-effectiveness of universal childhood hepatitis A vaccination in Chile.Entities:
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Year: 2005 PMID： 15964479 DOI： 10.1016/j.vaccine.2005.03.021
Source DB: PubMed Journal: Vaccine ISSN： 0264-410X Impact factor: 3.641