Literature DB >> 15963994

The properties of the mitochondrial megachannel in mitoplasts from human colon carcinoma cells are not influenced by Bax.

Silvia Campello1, Umberto De Marchi, Ildikò Szabò, Francesco Tombola, Jean-Claude Martinou, Mario Zoratti.   

Abstract

This paper explores the relationship between Bax and the mitochondrial permeability transition pore (PTP). Isolated human colon tumor (HCT116) Bax- mitochondria exposed to recombinant Bax exhibited a slow, cyclosporin A-sensitive swelling, but only at [Bax]>200 nM. The amount of Bax incorporated was much higher than that found in organelles isolated from HCT116 Bax+ staurosporine- or etoposide-treated apoptotic cells, casting doubts on the significance of the putative PT induction for apoptosis. Bax did not influence the electrophysiological properties of an approximately 1 nS channel ascribed to the Ca2+-dependent mitochondrial permeability transition pore. These observations indicate that the PTP is independent of Bax.

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Year:  2005        PMID： 15963994     DOI： 10.1016/j.febslet.2005.05.055

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  8 in total

Review 1.  The still uncertain identity of the channel-forming unit(s) of the mitochondrial permeability transition pore.

Authors:  Christopher P Baines; Manuel Gutiérrez-Aguilar
Journal:  Cell Calcium       Date:  2018-05-16       Impact factor: 6.817

Review 2.  Modulation of the matrix redox signaling by mitochondrial Ca(2.).

Authors:  Jaime Santo-Domingo; Andreas Wiederkehr; Umberto De Marchi
Journal:  World J Biol Chem       Date:  2015-11-26

3.  The unique histidine in OSCP subunit of F-ATP synthase mediates inhibition of the permeability transition pore by acidic pH.

Authors:  Manuela Antoniel; Kristen Jones; Salvatore Antonucci; Barbara Spolaore; Federico Fogolari; Valeria Petronilli; Valentina Giorgio; Michela Carraro; Fabio Di Lisa; Michael Forte; Ildikó Szabó; Giovanna Lippe; Paolo Bernardi
Journal:  EMBO Rep       Date:  2017-12-07       Impact factor: 8.807

4.  The role of GSH efflux in staurosporine-induced apoptosis in colonic epithelial cells.

Authors:  Magdalena L Circu; Sarah Stringer; Carol Ann Rhoads; Mary Pat Moyer; Tak Yee Aw
Journal:  Biochem Pharmacol       Date:  2008-09-17       Impact factor: 5.858

5.  Mitochondrial Ca(2+) Processing by a Unit of Mitochondrial Ca(2+) Uniporter and Na(+)/Ca(2+) Exchanger Supports the Neuronal Ca(2+) Influx via Activated Glutamate Receptors.

Authors:  Mikhail Strokin; Georg Reiser
Journal:  Neurochem Res       Date:  2016-02-03       Impact factor: 3.996

6.  The interactions of cobalt(II) with mitochondria from rat liver.

Authors:  Marcantonio Bragadin; Antonio Toninello; Mario Mancon; Sabrina Manente
Journal:  J Biol Inorg Chem       Date:  2007-03-03       Impact factor: 3.862

7.  Electro-pharmacological profiles of two brain mitoplast anion channels: Inferences from single channel recording.

Authors:  Javad Fahanik-Babaei; Farzad Shayanfar; Naser Khodaee; Reza Saghiri; Afsaneh Eliassi
Journal:  EXCLI J       Date:  2017-04-18       Impact factor: 4.068

8.  Targeting Mitochondrial Calcium Uptake with the Natural Flavonol Kaempferol, to Promote Metabolism/Secretion Coupling in Pancreatic β-cells.

Authors:  Flavien Bermont; Aurelie Hermant; Romy Benninga; Christian Chabert; Guillaume Jacot; Jaime Santo-Domingo; Marine R-C Kraus; Jerome N Feige; Umberto De Marchi
Journal:  Nutrients       Date:  2020-02-19       Impact factor: 5.717
  8 in total

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