| Literature DB >> 15963721 |
Nobuaki Matsumori1, Yuichi Umegawa, Tohru Oishi, Michio Murata.
Abstract
The first stably fluorinated derivative of amphotericin B2 with a fluorine atom in the macrolide skeleton was synthesized using an electrophilic fluorination reagent, Selectfluor. The derivative 2 showed hemolytic, K+ permeable, and antifungal activities similar to those of AmB and thus was expected to be a powerful tool for NMR-based investigations on the mechanism of ion-channel formation by amphotericin B.Entities:
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Year: 2005 PMID： 15963721 DOI： 10.1016/j.bmcl.2005.05.058
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823