| Literature DB >> 15963720 |
Osvaldo J Donadel1, Eduardo Guerreiro, Alejandra O María, Graciela Wendel, Ricardo D Enriz, Oscar S Giordano, Carlos E Tonn.
Abstract
A series of sesquiterpene compounds possessing both eudesmane and eremophilane skeletons were tested as gastric cytoprotective agents on male Wistar rats. The presence of an alpha,beta-unsaturated aldehyde on the C-7 side chain together with a hydroxyl group at C-4 is the requirement for the observed antiulcerogenic activity. In an attempt to establish new molecular structural requirements for this gastric cytoprotective activity, a structure-activity study was performed.Entities:
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Year: 2005 PMID： 15963720 DOI： 10.1016/j.bmcl.2005.05.053
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823