Literature DB >> 15963606

Synthesis and inhibition of PGE2 production of 6,8-disubstituted chrysin derivatives.

Haeil Park1, Tran Thanh Dao, Hyun Pyo Kim.   

Abstract

A series of 6,8-disubstituted chrysin derivatives have been synthesized and evaluated for their PGE2 inhibitory activities. 6,8-Disubstituted chrysin derivatives were obtained from naturally occurring chrysin by halogenation, oxidation, thiomethylation and C-C cross coupling reaction. Among the compounds investigated, 6,8-dibromochrysin (2), 6,8-diiodochrysin (4), 6,8-dimethylthiochrysin (9) and 6,8-dimethoxychrysin (11) showed as strong inhibitory activities of PGE2 production from LPS-induced RAW 264.7 cells as wogonin, a well known natural flavone having strong and selective COX-2 inhibitory activity.

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Year:  2005        PMID： 15963606     DOI： 10.1016/j.ejmech.2005.04.013

Source DB:  PubMed          Journal:  Eur J Med Chem        ISSN： 0223-5234            Impact factor:   6.514


  7 in total

1.  Design, synthesis and 3D-QSAR study of cytotoxic flavonoid derivatives.

Authors:  Lili Ou; Shuang Han; Wenbo Ding; Zhe Chen; Ziqi Ye; Hongyu Yang; Goulin Zhang; Yijia Lou; Jian-Zhong Chen; Yongping Yu
Journal:  Mol Divers       Date:  2010-11-14       Impact factor: 2.943

2.  8-Bromo-7-methoxychrysin-induced apoptosis of hepatocellular carcinoma cells involves ROS and JNK.

Authors:  Xiao-Hong Yang; Xing Zheng; Jian-Guo Cao; Hong-Lin Xiang; Fei Liu; Yuan Lv
Journal:  World J Gastroenterol       Date:  2010-07-21       Impact factor: 5.742

3.  Discovery of human TyrRS inhibitors by structure-based virtual screening, structural optimization, and bioassays.

Authors:  Shenzhen Huang; Xiang Wang; Guifeng Lin; Jie Cheng; Xiuli Chen; Weining Sun; Rong Xiang; Yamei Yu; Linli Li; Shengyong Yang
Journal:  RSC Adv       Date:  2019-03-22       Impact factor: 4.036

4.  The Elbs and Boyland-Sims peroxydisulfate oxidations.

Authors:  E J Behrman
Journal:  Beilstein J Org Chem       Date:  2006-11-07       Impact factor: 2.883

Review 5.  Emerging cellular and molecular mechanisms underlying anticancer indications of chrysin.

Authors:  Marjan Talebi; Mohsen Talebi; Tahereh Farkhondeh; Jesus Simal-Gandara; Dalia M Kopustinskiene; Jurga Bernatoniene; Saeed Samarghandian
Journal:  Cancer Cell Int       Date:  2021-04-15       Impact factor: 5.722

Review 6.  The Long Search for Pharmacologically Useful Anti-Inflammatory Flavonoids and Their Action Mechanisms: Past, Present, and Future.

Authors:  Hyun Pyo Kim
Journal:  Biomol Ther (Seoul)       Date:  2022-03-01       Impact factor: 4.634

7.  Halogenated Chrysins Inhibit Dengue and Zika Virus Infectivity.

Authors:  Aphinya Suroengrit; Wanchalerm Yuttithamnon; Pimsiri Srivarangkul; Saran Pankaew; Krongkan Kingkaew; Warinthorn Chavasiri; Siwaporn Boonyasuppayakorn
Journal:  Sci Rep       Date:  2017-10-20       Impact factor: 4.379
  7 in total

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