| Literature DB >> 15963510 |
Hongliang Zong1, Zejuan Li, Liyun Liu, Yi Hong, Xiaojing Yun, Jianhai Jiang, Yayun Chi, Hanzhou Wang, Xiaoyun Shen, Yun Hu, Ziyue Niu, Jianxin Gu.
Abstract
CDK11(p58), a 58kDa protein of the PITSLRE kinase family, plays an important role in cell cycle progression, and is closely related to cell apoptosis. To gain further insight into the function of CDK11(p58), we screened a human fetal liver cDNA library for its interacting proteins using the yeast two-hybrid system. Here we report that histone acetyltransferase (HAT) HBO1, a MYST family protein, interacts with CDK11(p58) in vitro and in vivo. CDK11(p58) and HBO1 colocalize in the cell nucleus. Recombinant CDK11(p58) enhances the HAT activity of HBO1 significantly in vitro. Meanwhile, overexpression of CDK11(p58) in mammalian cells leads to the enhanced HAT activity of HBO1 towards free histones. Thus, we conclude that CDK11(p58) is a new interacting protein and a novel regulator of HBO1. Both of the proteins may be involved in the regulation of eukaryotic transcription.Entities:
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Year: 2005 PMID： 15963510 DOI： 10.1016/j.febslet.2005.05.039
Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124